Ketamine: From Neurobiology to Emergency and Anesthesia Care, Volume 1 discusses the latest advances in neuroscientific, translational, and clinical research, as well as practical applications of the essential drug racemic ketamine and its enantiomers esketamine and arketamine. Volume I covers ketamine's basic pharmacology and biology, as well as clinical developments in neurophysiology and neuroimaging with an emphasis on topics of consciousness and neuropsychiatric disorders such as depression. Pharmacokinetic and pharmacodynamic specifics with ketamine and its various administration routes are presented. The book also deals with racemic and esketamine's significance in clinical care of (prehospital) emergencies and trauma. The importance of ketamine in various anesthesia scenarios is addressed, including maternal and pediatric anesthesia, multimodal regimen, opioid-free anesthesia, and approaches to increase the quality of perioperative recovery. Periprocedural sedation with ketamine is described and potential benefits of ketamine for patient safety in neurosurgical anesthesia and sedation discussed.

This Neuromethods volume offers concise details and advice regarding ketamine therapy from top researchers and clinician scientists. These insights are key to success in research and, most importantly, to improving patient outcomes. Ketamine: From Neurobiology to Emergency and Anesthesia Care, Volume 1 is a comprehensive, up-to-date resource and essential reference for both researchers and clinicians. People all around the world are substantially interested in ketamine, and racemic and es- ketamine's applications in medicine are rapidly expanding.

This book is complemented by Ketamine: Pain Management, Critical Care, Depression, and Resource-Poor Setting, Volume II .

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Klappentext

Ketamine: From Neurobiology to Emergency and Anesthesia Care, Volume 1 discusses the latest advances in neuroscientific, translational, and clinical research, as well as practical applications of the essential drug racemic ketamine and its enantiomers esketamine and arketamine. Volume I covers ketamine’s basic pharmacology and biology, as well as clinical developments in neurophysiology and neuroimaging with an emphasis on topics of consciousness and neuropsychiatric disorders such as depression. Pharmacokinetic and pharmacodynamic specifics with ketamine and its various administration routes are presented. The book also deals with racemic and esketamine’s significance in clinical care of (prehospital) emergencies and trauma. The importance of ketamine in various anesthesia scenarios is addressed, including maternal and pediatric anesthesia, multimodal regimen, opioid-free anesthesia, and approaches to increase the quality of perioperative recovery. Periprocedural sedation with ketamine is described and potential benefits of ketamine for patient safety in neurosurgical anesthesia and sedation discussed. This Neuromethods volume offers concise details and advice regarding ketamine therapy from top researchers and clinician scientists. These insights are key to success in research and, most importantly, to improving patient outcomes. Ketamine: From Neurobiology to Emergency and Anesthesia Care, Volume 1 is a comprehensive, up-to-date resource and essential reference for both researchers and clinicians. People all around the world are substantially interested in ketamine, and racemic and es- ketamine’s applications in medicine are rapidly expanding. This book is complemented by Ketamine: Pain Management, Critical Care, Depression, and Resource-Poor Setting, Volume II.

Inhalt

. The Global Importance of Ketamine for Medical Care.- Ketamine's Multifaceted Neuropharmacological and Neurobiological Actions.- The Neuroplastic Narrative of Antidepressant Ketamine Involves Early and Sustained Effects That Counteract Mechanisms Underlying Stress, Inflammation, and Neurodegeneration.- The Conundrums in Behavioral Animal Research and Some Findings with Ketamine.- Preclinical Studies on Ketamine and Its Enantiomers with Translational Significance.- (Es-)Ketamine and the Macro- and Microcirculation: What Do We Know?.- Ketamine in Translational Neuroscience: A Brief Introduction.- Neurophysiological Markers of (Dis)Connectedness: Insights from Ketamine.- Integrated Bioinformatics to Explore Molecular Targets of Esketamine and Arketamine in Antidepressant and Antisuicidal Action.- Analgesia with Ketamine and Its Metabolites: Mechanisms and Effects.- A Look to Classical Psychedelics and Atypic Dissociative Ketamine: Some Basics for Approaches to Medical Conditions.- Altered States of Consciousness Induced by Subanesthetic Ketamine Influence Differential Effects on Negative Affect Circuitry in Response to Emotional Stimulation in Nonclinical Volunteers.- Electroencephalography-Vigilance Measures in Response to Ketamine Effects in Major Depressive Disorder.- The Dynamic Processes Induced by Ketamine and their Potential for Augmented Treatment Strategies to Approach Neuropsychiatric Disorders.- Patients and Healthy Volunteers Are Not the Same: The Distinct Responses to Ketamine.- Time-Domain Functional Near-Infrared Spectroscopy for Bedside Assessment of Cerebrovascular Hemodynamics Induced by Subanesthetic Dose Ketamine.- Pharmacokinetics and Pharmacodynamics of Ketamine.- Is There a Difference in Ketamine Enantiomer Binding to Human Serum Albumin?.- Oral Racemic Ketamine and Esketamine: Emerging Indications and Future Directions.- Prolonged Release Ketamine Tablets: Isomer Pharmacokinetics and Metabolites in Human Volunteers.- Factors Affecting Ketamine Metabolism within the Cytochrome P450 System.- Ketamine in Prehospital Emergency Medicine.- An Update: Ketamine in Trauma Care, Rapid Sequence Intubation, and Beyond.- Procedural Sedation and Analgesia with Spontaneous Ventilation Outside the Operating Room in Non-Emergency Scenario and Ketamine.- Ketamine for Conscious Sedation in Deep Brain Stimulation Surgery.- Esketamine: Essential Differences Compared to Worldwide Used Racemic Ketamine and a Synopsis of its Perioperative Benefits and Safety.- Ketamine: Relief of Maternal Distress During Cesarean Section and Labor, and the Balance between Benefits and Potential Neonatal Neurodevelopmental Risks.- Ketamine for Treatment of Severe Postpartum Depression in Lactating Mothers: What is Known?.- Achieving Pediatric Anesthesia and Analgesia Goals with Minimum Unwanted Impact Is Not Just Drug Dose-Titration in Little Adults: Key Aspects with Ketamine in Three Challenging Situations.- Ketamine as an Adjuvant in Anesthesia for Neurosurgery with Intraoperative Neurophysiological Monitoring: Last Resort or Absolute Preference?.- The Scientific Exploration of Ketamine's Future Role in Anesthesia.