Ketamine: From Neurobiology to Emergency and Anesthesia Care, Volume 1 discusses the latest advances in neuroscientific, translational, and clinical research, as well as practical applications of the essential drug racemic ketamine and its enantiomers esketamine and arketamine. Volume I covers ketamine's basic pharmacology and biology, as well as clinical developments in neurophysiology and neuroimaging with an emphasis on topics of consciousness and neuropsychiatric disorders such as depression. Pharmacokinetic and pharmacodynamic specifics with ketamine and its various administration routes are presented. The book also deals with racemic and esketamine's significance in clinical care of (prehospital) emergencies and trauma. The importance of ketamine in various anesthesia scenarios is addressed, including maternal and pediatric anesthesia, multimodal regimen, opioid-free anesthesia, and approaches to increase the quality of perioperative recovery. Periprocedural sedation with ketamine is described and potential benefits of ketamine for patient safety in neurosurgical anesthesia and sedation discussed.

This Neuromethods volume offers concise details and advice regarding ketamine therapy from top researchers and clinician scientists. These insights are key to success in research and, most importantly, to improving patient outcomes. Ketamine: From Neurobiology to Emergency and Anesthesia Care, Volume 1 is a comprehensive, up-to-date resource and essential reference for both researchers and clinicians. People all around the world are substantially interested in ketamine, and racemic and es- ketamine's applications in medicine are rapidly expanding. This book is complemented by Ketamine: Pain Management, Critical Care, Depression, and Resource-Poor Setting, Volume II.