Ketamine: Pain Management, Critical Care, Depression, and Resource-Poor Settings, Volume II discusses the latest advances in neuroscientific, translational, and clinical research, as well as practical applications of the essential drug racemic ketamine and its enantiomers esketamine and arketamine. In addition to emphasizing ketamine's benefits in the management of perioperative and chronic pain, Volume II describes the substances' importance and potential for specific situations in intensive and neurocritical care, such as difficult sedation in seriously ill COVID-19 patients. The immense clinical improvements achieved with racemic and es- ketamine in patients with major depressive disorders and those who have not responded to other antidepressant treatments are highlighted, and practical treatment regimen are presented. Beyond, ketamine's potential utility in other severe mental health issues such as substance use disorders is described. It is very important to note ketamine's unique significance for healthcare provision in resource-constrained countries and situations of war and disaster, which is another focus of Volume II. The book closes with expert- and evidence-based considerations and prospects regarding ketamine's role in enhancing medical care in specific circumstances such as in mountain medicine, cardiac anesthesia, and microgravity, for example in the context of a future Mars habitat.

This Neuromethods series offers concise details and advice regarding ketamine therapy from top researchers and clinician scientists. These insights are instrumental in achieving success and, most notably, in enhancing patient outcomes. Ketamine: Pain Management, Critical Care, Depression, and Resource-Poor Settings, Volume II is a comprehensive, up-to-date, and valuable resource and reference for researchers and clinicians alike. The global interest in ketamine is substantial, and the uses of racemic ketamine and esketamine in medicine are growing quickly.

This book is complemented by Ketamine: From Neurobiology to Emergency and Anesthesia Care, Volume I.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt

Ketamine for Acute Postoperative Pain Management and Prevention of Chronic Postsurgical Pain: What Do Recent Meta-Analysis Teach?.- Perioperative Esketamine and Pain Relief: Endeavors to Optimize Use Schedules, Combination Regimen, Opioid-Sparing, and the Strive Not to Negatively Impact Upon Natural Post-Surgical Healing Processes.- Ketamine as an Adjuvant to Local and Regional Anaesthesia? Efficacy and Safety Considerations.- Relief from Chronic Neuropathic Pain with Ketamine but Increased Burden of Psychedelic Adverse Effects?.- Therapy of Chronic Pain in Children is Challenging: Is Ketamine a Reasonable Choice?.- How about Esketamine for Sedation of Critically Ill COVID-19 Patients? Background and Comments on Postulated Advantages and Real-Life Experience.- Adjunctive Ketamine for Sedation and Analgesia in Extracorporeal Membrane Oxygenation: Opportunities and Challenges.- Ketamine in the Neuro-Intensive Care Unit.- Racemic Ketamine and Esketamine for Treatment of Refractory and Super-Refractory Status Epilepticus.- Racemic or Es-Ketamine for Treatment of Septic Encephalopathy: First Preclinical and Clinical Research Data and Registered Clinical Trials.- The Global Prevalence of Depression Calls for Action: A Look to the Situation and Specifics with Ketamine.- Key Considerations for Practical Administration of Ketamine in Severe Depression, and its Use in Community Care in Edmonton, AB, Canada.- Comparing Intravenous Racemic Ketamine and Intranasal Esketamine for Treatment-Resistant Depression: A Clinical Dilemma.- Intranasal Esketamine for Management of Treatment-Resistant Depression: Evidence of Efficacy and Safety, and Use in Clinical Practice.- Arketamine: Unapproved but Promising Antidepressant with Multiple Brain Benefits.- Ketamine or Electroconvulsive Therapy as Treatment Approach to Severe Depression: The Necessity of More Personalized Management.- Therapeutic Ketamine in Youth with Major Depression Versus Illicit Use: Initial Clinical Findings with Short-Term Benefits and Long-Term Unknowns.- Future Directions of Esketamine Nasal Spray Continuation in Treatment-Resistant Depression.- Ketamine for Treatment of Addiction in Alcohol, Opioid, and Cocaine Use Disorder.- Anesthesia in Low-Income and Lower Middle-Income Countries and the Important Role of Ketamine for Care Provision.- Snakebites, Envenomation, and Treatment of Snakebite Pain with Ketamine.- Ketamine: Anaesthesia and Analgesia in War Zones and Disasters, and the Scheduling Issue in Resource-Limited Countries.- Ketamine and Esketamine for the Treatment of Refractory Status Epilepticus Induced by Organophosphorus Compounds.- Ketamine for Emergency Medicine in the Mountains and at High Altitude.- Unrealized Capital: Potential Roles for Ketamine, Hypnotherapy, and Virtual Reality in Cardiac Anesthesia.- Ketamine in Microgravity.