This volume provides readers with an overview of translational paths that can be used to study the pathophysiology of Parkinson's Disease and atypical parkinsonism, including molecular processes, tissue integrity, and cerebral networks during inflammatory and neurodegenerative processes. The chapters in this book are organized into three parts and cover topics such as new developments of cerebral circuit characterizations and computational neuroscience for the description of the brain's transition through disease stages; static and dynamic systemic changes with clinical and functional outcome measures; and atypical syndromes such as neurodegenerations, immunological processes, and progressive disease states. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and comprehensive, Translational Methods for Parkinson's Disease and Atypical Parkinsonism Research is a valuable resource that provides a new perspective on the disease from a scientific and clinical point of view, and highlights the importance of available and emerging technologies.

Includes cutting-edge methods and protocols Provides step-by-step detail essential for reproducible results Contains key notes and implementation advice from the experts

Inhalt

Pathophysiological Basis of Neurodegeneration in PD.- The Role of Alpha-Synuclein Pathology.- Crosstalk Between the Immune and Nervous Systems.- Role of Microglia for PD Pathology.- Toxic-Induced Rodent Models of Parkinson's Disease.- Studying Neuropsychiatric Symptoms, Depression, Anxiety in Parkinson's Disease.- Memory Deficits and Their Neuronal Substrates in Idiopathic Morbus Parkinson.- Translational Value of CSF and Serum Markers.- The Use of Next Generation Sequencing in Diagnosing Inherited Atypical Parkinsonian Disorders.- Measuring Functional Impairments using Novel Technologies.- Exploring Translational Paths in PD and Atypical Parkinsonism with Human Structural MRI.- A Practical Guide to Metabolic and Molecular Imaging in Atypical Parkinsonism.- Network Vulnerability in Parkinson's Disease.- Exploring Translational Paths in PD Studies with Invasive Electrophysiology.- Non-Invasive Neurostimulation Studies in PD.- Deep Brain Stimulation as a Tool to Study the Neural Basis of Decision-Making and Motor Control in Parkinson's Disease.- Translational View on Therapeutic Strategies and Upcoming Issues: Stem Cells and Brain Organoids Approaches for Parkinson's Disease Therapy.- Translating Therapeutic Strategies for Genetic PD Syndromes.