Animal Models of Epilepsy

In this book, investigators examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species. This is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.

With its complex anatomical, molecular, electrophysiological and behavioral components, epilepsy provides the neuroscientist with nearly boundless opportunities to examine basic neurobiological mechanisms. In Animal Models of Epilepsy: Methods and Innovations, prominent investigators in the field examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species such as Drosophila melanogaster (fruit flies), Caenorhabditis elegans (worms), Xenopus laevis (tadpoles) and Danio rerio (zebrafish). While covering some traditional models, the volume also explores the newest innovations like modeling seizure activity in silica and advanced strategies for seizure detection and gene therapy. As a volume in the successful Neuromethods(TM) series, the chapters provide clear, step-by-step protocols and thought-provoking reviews of the most recent advancements in the field.

Comprehensive and cutting-edge, Animal Models of Epilepsy: Methods and Innovations is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.

Provides an easily accessible reference for emerging animal models of epilepsy written by leading researchers in the field

Details the latest innovations and methodologies currently being applied in the field of epilepsy research

Covers a wide range of species and approaches

Presents a variety of experimental strategies, covering simple model organisms, imaging and modeling technologies, gene therapy and genetic approaches to animal model development

Moves beyond traditional animal models to encompass organisms and strategies that are at the cutting-edge of neuroscience

Includes supplementary material: sn.pub/extras

Inhalt

1. The Nematode, C. elegans, as an Emerging Model for Investigating Epilepsy Cody J. Locke, Kim A. Caldwell, and Guy A. Caldwell 2. The Genetics and Molecular Biology of Seizure Susceptibility in Drosophila Juan Song and Mark A. Tanouye 3. The Albino Xenopus laevis Tadpole as a Novel Model of Developmental Seizures D. Sesath Hewapathirane and Kurt Haas 4. Zebrafish as a Simple Vertebrate Organism for Epilepsy Research Scott C. Baraban 5. Modeling Tuberous Sclerosis Complex: Brain Development and Hyperexcitability Kevin C. Ess 6. BK Potassium Channels Mutations Affecting Neuronal Function and Epilepsy David Petrik, Qing H. Chen, and Robert Brenner 7. Mouse Models of Benign Familial Neonatal Convulsions (BFNC): Mutations in KCNQ (Kv7) Genes Nanda A. Singh, James F. Otto, Mark F. Leppert, H. Steve White, and Karen S. Wilcox 8. Interneuron Loss as a Cause of Seizures: Lessons from Interneuron-Deficient Mice Dorothy Jones-Davis, Maria-Elisa Calcagnotto, and Joy Y. Sebe 9. Imaging Seizure Propagation In Vitro Andrew J. Trevelyan and Rafael Yuste 10. Complexity Untangled: Large-Scale Realistic Computational Models in Epilepsy Robert J. Morgan and Ivan Soltesz 11. Organotypic Hippocampal Slice Cultures as a Model of Limbic Epileptogenesis Suzanne B. Bausch 12. Seizure Analysis and Detection In Vivo Javier Echauz, Stephen Wong, and Brian Litt 13. Viral Vector Gene Therapy for Epilepsy Stacey B. Foti, Shelley J. Russek, Amy R. Brooks-Kayal, and Thomas J. McCown 14. Neural Stem Cells in Experimental Mesial Temporal Lobe Epilepsy Michelle M. Kron and Jack M. Parent