Mood and Anxiety Related Phenotypes in Mice

World-renowned researchers outline behavioral approaches used in characterizing mood and anxiety-related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds.

Affecting approximately twenty percent of the world population, mood and anxiety disorders have been the subject of ever-increasing research. This increased research parallels a remarkable growth in the use of the laboratory mouse as a tool to understand the biological and genetic basis of mood and anxiety disorders as well as to develop improved treatments. In Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, world-renowned researchers provide an overview of behavioral approaches utilized in the characterization of mood and anxiety related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds. As a volume in the successful Neuromethods™ series, the chapters provide authoritative reviews including up-to-date detailed protocols of the most commonly used approaches in the field.

Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests is an ideal resource for scientists actively pursuing or interested in establishing behavioral protocols in their laboratories, while also serving as a reference for those students, scientists, and practitioners who have an interest in better understanding the preclinical behavioral methods used in mood and anxiety research.

Provides an easily accessible reference volume for methods used in the characterization of mood and anxiety related phenotypes in mice Covers a wide range of behavioral assays used to assess the efficacy of potential novel antidepressant and anxiolytic compounds Features contributions by world-renowned scientists with broad experiences in the development and application of behavioral tasks in mice Fills the void of resources for detailed protocols specifically for the study of mood and anxiety disorders as opposed to the several books that provide broad overviews related to the behavioral characterization of mice Serves as a reference for those students, scientists and practitioners who want to better understand behavioral approaches used in mood and anxiety research as well as a resource for scientists using behavioural protocols in their laboratories Includes supplementary material: sn.pub/extras

Klappentext

Affecting approximately twenty percent of the world population, mood and anxiety disorders have been the subject of ever-increasing research. This increased research parallels a remarkable growth in the use of the laboratory mouse as a tool to understand the biological and genetic basis of mood and anxiety disorders as well as to develop improved treatments. In Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, world-renowned researchers provide an overview of behavioral approaches utilized in the characterization of mood and anxiety related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds. As a volume in the successful Neuromethods(TM) series, the chapters provide authoritative reviews including up-to-date detailed protocols of the most commonly used approaches in the field. Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests is an ideal resource for scientists actively pursuing or interested in establishing behavioral protocols in their laboratories, while also serving as a reference for those students, scientists, and practitioners who have an interest in better understanding the preclinical behavioral methods used in mood and anxiety research.

Inhalt
The Open Field Test.- Analysis of Grooming Behavior and Its Utility in Studying Animal Stress, Anxiety, and Depression.- Digging in Mice: Marble Burying, Burrowing, and Direct Observation Reveal Changes in Mouse Behavior.- Circadian and Light Modulation of Behavior.- Ultrasonic Vocalizations by Infant Mice: An Ethological Expression of Separation Anxiety.- The Forced Swimming Test in Mice: A Suitable Model to Study Antidepressants.- The Tail-Suspension Test: A Model for Characterizing Antidepressant Activity in Mice.- Stress-Induced Hyperthermia in the Mouse.- Factors of Reproducibility of Anhedonia Induction in a Chronic Stress Depression Model in Mice.- Learned Helplessness in Mice.- The Mouse LightDark Box Test.- Using the Elevated Plus Maze as a Bioassay to Assess the Effects of Naturally Occurring and Exogenously Administered Compounds to Influence Anxiety-Related Behaviors of Mice.- Novelty-Induced Hypophagia.- Acute and Chronic Social Defeat: Stress Protocols and Behavioral Testing.- Reduction of Submissive Behavior Model for Antidepressant Drug Testing in Mice.- Mice Models for the Manic Pole of Bipolar Disorder.