Transgenic and Mutant Tools to Model Brain Disorders

As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important. The refinement of molecular genetic methods has continued to broaden our understanding of the genetic factors associated with a variety of disorders. In "Transgenic and Mutant Tools to Model Brain Disorders", leading scientists specializing in this field contribute a timely collection of recent advances featuring a vast array of topics in order to contribute to the diverse approaches taken toward the evaluation of genetically modified models in biomedical research. Opening with several chapters covering general aspects of genetically modified animal models, the book then continues with detailed chapters on models of specific human brain disorders, including OCD, Rett Syndrome, anxiety disorders, depression, and schizophrenia. As a volume in the successful Neuromethods™ series, the chapters provide authoritative reviews covering the most commonly used approaches in the field.

Cutting-edge and concise, "Transgenic and Mutant Tools to Model Brain Disorders" offers a comprehensive and descriptive overview on a variety of topics in neuroscience and biological psychiatry.

Provides an easily accessible reference volume for animal models in behavioral neuroscience research Details the process of turning a biological observation into a high-throughput screen Covers a wide range of species from zebrafish to rats Addresses a wide spectrum of brain disorders, from anxiety to schizophrenia Presents a modular approach to experimental modelling of brain disorders Comprehensive guide to translational biopsychiatry research focusing on genetic factors in brain disorders

Inhalt
General Approaches.- Mutant and Transgenic Zebrafish in Modeling Neurobehavioral Disorders.- Knockout and Mutant Rats.- Rat Mutants with Lateralized Rotational Behavior for Studying Disturbances in Cerebral Asymmetries and Their Involvement in Brain Disorders.- GABAA Receptor ?1 Subunit (Gabra1) Knockout Mice: Review and New Results.- Basal Ganglia Disorders in Genetic Models and Experimentally Induced Lesions.- Estrogen-Deficient Mouse Models in the Study of Brain Injury and Disease.- Specific Brain Disorders.- The Utility of Genetically Modified Animals in Modeling OCD-Spectrum Disorders.- Investigating Rett Syndrome Through Genetic Mouse Models: Presymptomatic, Clearly Symptomatic Phases, and Innovative Therapeutic Approaches.- Genetic Animal Models of Anxiety.- Genetic Animal Models of Depression.- Environmental Enrichment and GeneEnvironment Interactions in Mouse Models of Brain Disorders.- Mutant and Transgenic Tools in Modeling Schizophrenia.