How can we link the critical observations performed at autopsy with the events that occur over the previous twenty years of Alzheimer's Disease? This is the problem posed to a group of our colleagues who are using state-of-the-art neural imaging methods in patients and in animal models to illuminate the natural history of the disease - in the living brain.

Klappentext

From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer's Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas. Plaques follow their own temporal course, with widespread cortical deposits occurring even early in a disease process. The whole process may well take twenty years, the first half of which may be without overt symptoms.

Inhalt

Neuropathology of Alzheimer's Disease as Seen in Fixed Tissues.-Cerebrospinal Fluid Biomarkers for the Diagnosis of Alzheimer's Disease.- The Living Brain and Alzheimer's Disease.- In Vivo Imaging of Alzheimer Pathology in Transgenic Mice Using Multiphoton Microscopy.- In Vivo Magnetic Resonance of Amyloid Plaques in Alzheimer's Disease Model Mice.- Measuring Progression in Alzheimer's Disease Using Serial MRI: 4D MRI.- Validating MRI Measures of Disease Stage and Progression in Alzheimer's Disease.- Dynamic Mapping of Alzheimer's Disease.- Development of Benzothiazole Amyloid-Imaging Agent (PIB) in Alzheimer's Disease Patients and Healthy Volunteers.- Mild Cognitive Impairment (MCI): Predicting Conversion to Clinically Probable Alzheimer's Disease with Fluoro-Deoxy-Glucose PET.- Subject Index