The book provides stimulating hypotheses about the possible role of growth factors in the generation of senile plaques, the process of degeneration and regeneration in Alzheimer's disease, the expression of the gene of NGF and the possible use of NGF in treatment.

Inhalt

Neurotrophic Factors and Neurodegenerative Diseases.- Survival, Regrowth, and Reconnection of Injured Retinal Ganglion Cells.- Localizing Expression of the Three Members of the Nerve Growth Factor Family to Neurons in the Brain.- Nerve Growth Factor: Studies Addressing its Expression and Actions in the Central Nervous System.- Nerve Growth Factor Gene Expression in Actively Growing Brain Glia.- Human Nerve Growth Factor Receptor Expression in the CNS of Transgenic Mice.- Involvement of Protein Kinase C in the Regulation of Nerve Growth Factor Synthesis: A Possible Cause of Impaired Trophic Supply in Alzheimer's Disease?.- Distribution and Characterization of ?-Nerve Growth Factor Receptors in Alzheimer's Disease.- Regulation of Nerve Growth Factor Synthesis in the Central Nervous System by Cytokines and Implications for the Treatment of Alzheimer's Disease.- Nerve Growth Factor Expression and Function in the CNS.- Nerve Growth Factor and Behavioral Recovery After Brain Damage in Rats.- Functional Impairments that Develop in Nerve Growth Factor-Sensitive Neuronal Projections in the PNS and CNS of Aged Rats Are Ameliorated by Dietary Interventions.- Morphological and Behavioral Effects of Basic Fibroblast Growth Factor and Heparin on Transplanted Fetal Dopaminergic Neurons and Astrocytes in the Denervated Rat Caudate-Putamen.- Acidic Fibroblast Growth Factor Localization and Basic Fibroblast Growth Factor Binding Sites in the Eye and Optic Nerve.- Synthetic Peptide Agonists and Antagonists of Basic Fibroblast Growth Factor: Increasing Cellular Specificity of a Multifunctional Growth Factor.- ACTH(4-10) Analog Potentiates Cognitive and Morphological Recovery After Frontal Cortex Lesions in Adult Rats.- Effects of Neurotrophic Factors on the Secretion and Metabolism of the Alzheimer Amyloid Precursor.- Nerve Growth Factor Induces Differential Splicing of ?-Amyloid Precursor mRNAs in the PC12 Cell Line.- The Role of Misdirected Plasticity in Plaque Biogenesis and Alzheimer's Disease Pathology.- The Neuritic Dystrophy of Alzheimer's Disease: Degeneration or Regeneration ?.