The book includes new data on imaging techniques, neuropathology, neurochemistry, and molecular biology. It provides a consistent interpretation of Alzheimer`s disease with respect to cerebral topography and its implications.

Inhalt

Topography of Alzheimer's Disease: Involvement of Association Neocortices and Connected Regions; Pathological, Metabolic and Cognitive Correlations; Relation to Evolution.- Cellular Pathology in Alzheimer's Disease: Implications for Corticocortical Disconnection and Differential Vulnerability.- Distribution of Neurochemical Deficits in Alzheimer's Disease.- Topography of Lesions in Alzheimer's Disease: A Challenge to Morphologists.- Computer Tomography and Study of the Anatomical Changes in Alzheimer's Disease.- Could "Leuko-araïosis" Be Secondary to Wallerian Degeneration in Alzheimer's Disease?.- Topographical Comparison of Lesions in Trisomy 21 and Alzheimer's Disease: A Study with PET, Anatomical and Neuropathological Investigations.- Cognitive Deficits and Local Metabolic Changes in Dementia of the Alzheimer's Type.- Patterns of Cerebral Metabolism in Degenerative Dementia.- Cortical Functional Impairment in Dementia of the Alzheimer Type: Studies with Positron Emission Tomography.- Brain Imaging with SPECT in Alzheimer's Disease.- Hemodynamic Subtypes of Dementia of the Alzheimer Type: Clinical and Neuropsychological Characteristics.- Nuclear Magnetic Resonance Study of Phospholipid Metabolites in Alzheimer's Disease.- Summary Comments on Presentations.