In this second edition of his highly acclaimed book, Christopher P. Cannon, MD, and a team of preeminent clinical investigators have thoroughly revised and expanded every chapter to reflect the recent explosion of clinical trials on the management of acute coronary syndromes (ACS). These world-renowned experts review: the newer tests, such as C reactive protein; a multimarker approach to diagnosis and risk stratification; new antiplatelet agents; and combinations of thrombolytic-anti- thrombotic regimens. They also discuss the latest developments in interventional cardiology (early invasive approach in higher risk ACS patients and the promise of drug-coated stents), and analyze cost-effectiveness in clinical trials to choose appropriate therapies. Current trial data are included, along with practical recommendations on how these data may be applied in daily practice.
Comprehensive and authoritative, Management of Acute Coronary Syndromes, Second Edition, succinctly presents cardiologists, internists, primary care and emergency physicians, fellows, and residents with an up-to-the-minute review of the many recent advances that have transformed our understanding of the pathophysiology, diagnosis, and management of patients with acute coronary syndromes.

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Part I. Pathophysiology The Spectrum of Myocardial Ischemia: The Paradigm of Acute Coronary Syndromes Christopher P. Cannon and Eugene Braunwald Linking Biochemistry, Vascular Biology, and Clinical Events in Acute Coronary Syndromes Richard C. Becker and Annemarie Armani Triggers of Acute Coronary Syndromes Peter M. Sapin and James E. Muller Insights into the Pathophysiology of Acute Ischemia Syndromes Using the TIMI Flow Grade, TIMI Frame Count, and TIMI Myocardial Perfusion Grade C. Michael Gibson, Sabina A. Murphy, and Jeffrey J. Popma Part II. Diagnosis Emergency Department Presentations of Acute Cardiac Ischemia J. Hector Pope and Harry P. Selker Early Identification and Treatment of Patients with Acute Coronary Syndromes Mary M. Hand and Costas T. Lambrew Serum Markers for Diagnosis and Risk Stratification in Acute Coronary Syndromes L. Kristin Newby, W. Brian Gibler, Robert H. Christenson, and E. Magnus Ohman Technologies to Diagnose Acute Ischemia Robert J. Zalenski, Joseph Lau, and Harry P. Selker Part III. ST-Segment Elevation Myocardial Infarction Thrombolytic Therapy Jeffrey L. Anderson and James S. Zebrack Primary Angioplasty Sorin J. Brener and Eric J. Topol Expanding the Access to Percutaneous Coronary Intervention for Patients Admitted to Community Hospitals Thomas P. Wharton, Jr. and Nancy Sinclair McNamara Antiplatelet and Anticoagulant Therapy Marc S. Sabatine and Ik-Kyung Jang b-Adrenergic Blockers, Calcium Channel Blockers, and Nitrates Yerem Yeghiazarians and Peter H. Stone Angiotensin Converting Enzyme Inhibitors After and During Acute Coronary Syndromes, and, in Particular, Myocardial Infarction Rodolfo Carrillo-Jimenez, Charles H. Hennekens, and Gervasio A. Lamas Risk Stratification: Exercise Testing, Imaging, and Cardiac Catheterization Sanjeev Puri, Hani A. Razek, and Bernard R. Chaitman Part IV. Non-ST-Segment Elevation Myocardial Infarction Anticoagulant Therapies, Marc Cohen. Antiplatelet Therapy Ian Conde-Pozzi and Neal S. Kleiman Thrombolytics and Invasive vs Conservative Strategies in Unstable Angina Ali Moustapha and H. Vernon Anderson Current Device Strategies in the Management of Acute Coronary Syndromes Kanwar P. Singh and C. Michael Gibson Part V. Special Aspects of Acute Coronary Syndromes Women and Acute Coronary Syndromes Jane A. Leopold and Alice K. Jacobs The Modern Strategy for Cardiogenic Shock Gary E. Lane and David R. Holmes, Jr. Myocardial Infarction in the Younger Patient James C. Fang and Jorge Plutzky Cholesterol Lowering Terje R. Pedersen and Serena Tonstad 'Secondary Prevention' of Myocardial Infarction Jorge Plutzky and Roger S. Blumenthal Cost and Cost-Effectiveness in Acute Coronary Syndromes William S. Weintraub Smoking Cessation Beth C. Bock and Bruce Becker Critical Pathways for Acute Coronary Syndromes Christopher P. Cannon and Patrick T. O'Gara Index