Molecular biology holds great promise for the development of new strategies for cancer prevention and treatment. In The Molecular Basis of Human Cancer, internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms of cancer induction. They also consider the future directions of research, including discussions of the exploitation of molecular targets for developing anticancer drugs, recent developments in gene therapy, and the appropriate use of molecular information in genetic counseling.
Up-to-date and forward-looking, The Molecular Basis of Human Cancer offers a critically integrated survey of the full range of state-of-the-art cancer molecular biology and genetics and constitutes indispensable reading for all cancer researchers today.

Klappentext

Internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, and skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms in cancer induction.

Inhalt

Part I. Introduction Cancer Epidemiology: Incidence and Etiology of Human Neoplasms William B. Coleman and Gregory J. Tsongalis Part II. Essential Concepts in Molecular Biology Essential Concepts and Techniques in Molecular Biology Sharon Collins Presnell Part III. Molecular Themes in Oncogenesis Cancer Genes John J. Reinartz Positive Mediators of Cell Proliferation in Neoplastic Transformation James N. Welch and Susan A. Chrysogelos Inactivation of Negative Growth Regulators During Neoplastic Transformation Kara N. Smolinski and Stephen J. Meltzer Part IV. Mechanisms of Mutation The Role of Genomic Instability in the Development of Human Cancer William B. Coleman and Gregory J. Tsongalis Chromosomes and Chromosomal Instability in Human Cancer Takashi Shimamoto and Kazuma Ohyashiki Hereditary Cancer Bruce M. Boman, Lael Melchert, and Jeremy Z. Fields Part V. Etiology of Human Cancers Evolution of Research in Cancer Etiology Lorenzo Tomatis and James Huff Cellular Responses to Chemical Carcinogens Edward L. Loechler, Bryan Henry, and Kwang-Young Seo Physical Agents in Human Carcinogenesis Cynthia R. Timblin, Yvonne Janssen-Heininger, and Brooke T. Mossman Viral Mechanisms of Human Carcinogenesis Felix Hoppe-Seyler and Karin Butz Part VI. Human Tumor Systems The Molecular Biology of Colorectal Carcinoma: Importance of the Wg/Wnt Signal Transduction Pathway J. Milburn Jessup, Gary Gallick, and Bo Liu Molecular Genetic Alterations in Primary Hepatocellular Neoplasms: Hepatocellular Adenoma, Hepatocellular Carcinoma, and Hepatoblastoma Joe W. Grisham The Molecular Basis of Breast Carcinogenesis April Charpentier and C. Marcelo Aldaz The Molecular Basis of Prostate Carcinogenesis Allen C. Gao and John T. Isaacs The Molecular Basis of Lung Carcinogenesis Kwun M. Fong, Yoshitaka Sekido, and John D. Minna The Molecular Basis of Skin Carcinogenesis Caterina Missero, Mariarosaria D'Errico, Gian Paolo Dotto, and Eugenia Dogliotti The Molecular Biology of Leukemias Arnold B. Gelb and L. Jeffrey Medeiros Molecular Genetic Applications to the Diagnosis of Non-Hodgkin's Lymphoma Gregory J. Tsongalis and William N. Rezuke Part VII. Future Directions Cancer Genetic Counseling Katherine Schneider, Kristen Shannon, Anu Chittenden, Elaine Hiller, and Stephanie Kieffer Molecular Genetic Diagnosis of Inherited Cancer Predisposition Elizabeth M. Petty and Beverly M. Yashar Novel Molecular Targets for Cancer Drug Discovery John K. Buolamwini Gene Therapy in the Treatment of Human Cancer Jesús Gómez-Navarro, Guadalupe Bilbao, and David T. Curiel