Although drug-nutrient interactions can produce therapeutic failure, adverse drug reactions, and altered nutritional status, many clinicians do not recognize this potential when prescribing drugs or understand that drug-nutrient interactions can be as important as drug-drug interactions. In Handbook of Drug-Nutrient Interactions, well-recognized and respected authorities comprehensively review many of the more common, and some less common, drug-nutrient interactions, detailing the mechanisms and clinical approaches to their effective management. Providing more than a simple listing of common interactions, this much needed work explores, in-depth, every major aspect of the problem, including drug and nutrient disposition, enzyme systems, the effects of nutritional status on drug disposition, and the influence of food, nutrients, and non-nutrient components on drug effects and disposition. The authors present the latest findings on the influence of medications on nutrient status and on those interactions relevant to life-cycle stages and to specific patient groups. Separate chapters examine the effects of caffeine, charcoal broiling, grapefruit juice, alcohol, garlic, ginko biloba, dietary minerals, folate, vitamins D and K, and calcium. Cutting-edge reviews offer detailed information on the major drugs affecting the cardiovascular and nervous systems, with emphasis on the antiepileptics. Extensive tables provide clinical recommendations and organize the data clearly to help the reader evaluate nutrition's critical role in optimizing drug efficacy, especially in at-risk populations. An extensive index and copious up-to-date references ensure rapid access to needed information and key citations.
Comprehensive and clinically oriented, Handbook of Drug-Nutrient Interactions provides health professionals in many areas of research and practice with the most up-to-date, well-referenced, and easy-to-understand survey of nutrition's central importance in optimizingdrug efficacy and avoiding adverse effects. It constitutes a benchmark in the field and should be on the desk of every prescribing healthcare professional as a key reference.

Klappentext

Although there is agreat deal ofliterature regarding drug-nutrientinteractions (DNis ), there are limited sources of up-to-date comprehensive information. The Handbook of Drug-Nutrient Interactions admirably fills this gap. The editors, Dr. Joseph 1. Boullata and Dr. Vincent T. Armenti, ha ve a wealth of experience in this therapeutic ar ea and ha ve assembled a fine cadre of chapter authors who have individually contributed their high level of expertise. As treatment for many diseases becomes increasingly complex with multiple drug therapies scheduled at varying times, the need to identify clinically significant DNis is an essential part of medication management. This is a shared responsibility between health care professionals to interpret available data and individualize an approach to therapy that is compatible with the patient' s disease state, life stage, and dietary intake. Awareness ofthe significance of drug-food interactions is generally lacking. Although many texts contain lengthy lists of possible interactions, few data are provided for the clinician to gain an understanding of the mechanism of action of the interaction and subsequently apply the information to a particular patient or group of patients. For example, in the management of patients with HN -AIDS who are taking complex prescribed drug regimens, herbal products, and nutritional supplements, many of which are affected by dietary intake, careful attention to D Nls is a critic al component of therapy. Clinicians need to take account of not only the well-documented interactions between drugs and nutrients, but also the less obvious effects on drug-nutrient disposition and metabolism.

Inhalt

I. Overview of Drug-Nutrient Interactions A Perspective on Drug-Nutrient Interactions Joseph I. Boullata and Jacqueline R. Barber Drug Disposition and Response Robert B. Raffa Drug-Metabolizing Enzymes and P-Glycoprotein Thomas K. H. Chang Nutrient Disposition and Response Francis E. Rosato, Jr. II. Influence of Nutritional Status on Drug Disposition and Effect The Impact of Protein-Calorie Malnutrition on Drugs Charlene W. Compher Influence of Obesity on Drug Disposition and Effect Joseph I. Boullata III. Influence of Food or Nutrients on Drug Disposition and Effect Drug Absorption With Food, David Fleisher Burgunda V. Sweet, and Ameeta Parekh Effects of Specific Foods and Non-Nutritive Dietary Components on Drug Metabolism Karl E. Anderson Grapefruit Juice-Drug Interaction Issues David G. Bailey Nutrients That May Optimize Drug Effects Imad F. Btaiche and Michael D. Kraft Dietary Supplement Interactions With Medication Jeffrey J. Mucksavage and Lingtak-Neander Chan Dietary Supplement Interaction With Nutrients Mariana Markell IV. Influence of Pharmaceuticals on Nutritional Status, Nutrient Disposition, and Effect Drug-Induced Changes to Nutritional Status Jane M. Gervasio Cardiac Drugs and Nutritional Status Honesto M. Poblete, Jr. and Raymond C. Talucci, II Drug-Nutrient Interactions Involving Folate Leslie Schechter and Patricia Worthington Effects of Antiepileptics on Nutritional Status Mary J. Berg Drug-Nutrient Interactions That Impact Mineral Status Sue A. Shapses, Yvette R. Schlussel, and Mariana Cifuentes V. Drug-Nutrient Interactions by Life Stage Drug-Nutrient Interactions in Infancy and Childhood Deborah A. Maka, Lori Enriquez,and Maria R. Mascarenhas Drug-Nutrient Interaction Considerations in Pregnancy and Lactation Kathleen L. Hoover, Marcia Silkroski, Leslie Schechter, and Patricia Worthington Drug-Nutrient Interactions in the Elderly Tanya C. Knight-Klimas and Joseph I. Boullata VI. Drug-Nutrient Interactions in Specific Conditions Drug-Nutrient Interactions in Patients With Cancer Todd W. Canada Drug-Nutrient Interactions in Transplantation Matthew J. Weiss, Vincent T. Armenti, and Jeanette M. Hasse Drug-Nutrient Interactions and Immune Function Adrianne Bendich and Ronit Zilberboim Drug-Nutrient Interactions in Patients With Chronic Infections Steven P. Gelone and Judith A. O'Donnell Antimicrobial-Nutrient Interactions: An Overview Allison Wood Wallace Drug-Nutrient Interactions in Patients Receiving Enteral Nutrition Carol J. Rollins Index