The Biology of Tumors

The Ninth Annual Pezcoller Symposium entitled "The Biology of Tumors" was held in Rovereto, Italy, June 4-7, 1997. It focused on the genetic mechanisms underlying het erogeneity of tumor cell populations and tumor cell differentiation, on interactions be tween tumor cells and cells of host defenses, and the mechanisms of angiogenesis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to phenomena concerned with cell regulation and cell interactions as determined by activated genes through the appropriate and timely media tion of gene products. Important methodologies that would allow scientists to measure dif ferentially genes and gene products and thus validate many of the mechanisms of control currently proposed were considered, as were the molecular basis of tumor recognition by the immune system, interactions between cells and molecular mechanisms of cell regula tion as they are affected by or implemented through these interactions. The molecular and cellular mechanisms of tumor vascularization were also discussed. It was recognized that angiogenesis provides a potential site of therapeutic intervention and this makes it even more important to understand the mechanisms underlying it. We wish to thank the participants in the symposium for their substantial contribu tions and their participation in the spirited discussions that followed. We would also like to thank Drs.

Klappentext

Proceedings of the Ninth Annual Pezcoller Symposium held in Rovereto, Italy, June 4-7, 1997

Zusammenfassung
The Ninth Annual Pezcoller Symposium entitled "The Biology of Tumors" was held in Rovereto, Italy, June 4-7, 1997. It focused on the genetic mechanisms underlying het­ erogeneity of tumor cell populations and tumor cell differentiation, on interactions be­ tween tumor cells and cells of host defenses, and the mechanisms of angiogenesis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to phenomena concerned with cell regulation and cell interactions as determined by activated genes through the appropriate and timely media­ tion of gene products. Important methodologies that would allow scientists to measure dif­ ferentially genes and gene products and thus validate many of the mechanisms of control currently proposed were considered, as were the molecular basis of tumor recognition by the immune system, interactions between cells and molecular mechanisms of cell regula­ tion as they are affected by or implemented through these interactions. The molecular and cellular mechanisms of tumor vascularization were also discussed. It was recognized that angiogenesis provides a potential site of therapeutic intervention and this makes it even more important to understand the mechanisms underlying it. We wish to thank the participants in the symposium for their substantial contribu­ tions and their participation in the spirited discussions that followed. We would also like to thank Drs.

Inhalt

1. The Role for ink4a in Melanoma Pathogenesis: One Gene, Two Products, Multiple Pathways.- 2. Identification and Characterization of Collaborating Oncogenes in Compound Mutant Mice.- 3. The Transcription Factor B-Myb Is Phosphorylated and Activated by Cyclin A/Cdk2.- 4. Distinct Dynamics and Regulatory Signal Transduction of Cell Migration: Lessons from Dendritic Cells, Tumor Cells, and T Lymphocytes.- 5. Genomic Instability in Sporadic Colorectal Cancer: A Destabilized Genome Producing Accelerated Cellular Evolution as the Fundamental Nature of Cancer.- 6. APC and the Early Events of Colon Cancer.- 7. Genome Scanning and Gene Discovery in Breast and Ovarian Cancer.- 8. Failure of Tumor Immunity Resulting from Inaccessibility of Activated Lymphocytes to Solid Tumors: The Possible Role of the Endothelium.- 9. Deciphering Molecular Circuitry Using High-Density DNA Arrays.- 10. Use of cDNA Microarrays to Assess DNA Gene Expression Patterns in Cancer.- 11. EH, a Novel Protein: Protein Interaction Domain.- 12. Deregulation of Cyclin D1 in Cancer.- 13. Dysregulation of Programmed Cell Death in Cancer toward a Molecular Understanding of Bcl-2.- 14. Characterization of Antigens Recognized by T Cells on Human Tumors.- 15. Identification of Human Tumor Antigens Using the B-Cell Repertoire.- 16. T Cell Tolerance versus Tumor Immunity or Autoimmunity.- 17. Manipulation of T Cell Activation in the Anti-Tumor Immune Response.- General Discussion.- 18. Cytokines and Tumor Immunogenicity: Toward an Appropriate Cancer Vaccine.- 19. T-Cell and NK-Mediated Surveillance of Cancer: A Delicate Balancing Act.- 20. Regulation of Leukocyte-Endothelial Cell Interactions in Tumor Immunity.- 21. Role of Endothelial versus Smooth Muscle Cells in Blood Vessel Formation.- 22. The Role of Vascular Endothelial Growth Factor in Tumor Angiogenesis.- 23. Tumor Microcirculation: Role in Delivery of Molecular and Cellular Medicine.