Cancer Genes

The seventh Annual Pezcoller Symposium entitled, Cancer Genes: Functional As pects, was held in Trento, Italy, June 14-16, 1995 and was focused on oncogenes func tion, tumor suppressor gene function, transcription regulation, cell cycle progression regulation and apoptosis, and the clinical implications of oncogene function and regula tion for prevention and therapy of cancer. With presentations at the cutting edge of pro gress and stimulating discussions, this Symposium addressed issues related to the mechanisms of control of cell growth and death by certain genes such as c-myc, src, fyns, bcl2, the function of cdk inhibitors, the functions of p53 and WTI, the mechanisms of transcriptional activation of specific oncogenes, the genetic characterization of certain he matological malignancies, the interference with specific sites along signal transduction and the genetic alterations of tumor immunity. We wish to thank the participants in the Symposium for their substantial contribu tions and their participation in the spirited discussions which followed. We would also like to thank Drs. Jane Azizkhan, Paolo Comoglio, Giulio Draetta~ David M. Livingston and Alex Matter for their essential input as members of the Program Committee, and Ms. A. Toscani for her invaluable assistance. The aid of the Bank Cassa di Risparmio di Trento and Rovereto, and the Municipal, Provincial and Regional Administrations in sup porting this Symposium through the Pezcoller Foundation are also acknowledged with deep appreciation. Finally, we wish to thank the staff of Plenum Publishing Corporation for their efficient cooperation in the production of these Proceedings.

Klappentext

Proceedings of the Seventh Pezcoller Symposium held in Trento, Italy, June 14-16, 1995

Zusammenfassung
Proceedings of the Seventh Pezcoller Symposium held in Trento, Italy, June 14-16, 1995

Inhalt

1. The Integrated Control of Cell Proliferation and Cell Viability.- 2. Control of Invasive Cell Growth by the Met Family Oncogenes.- 3. SRC Family Kinases and the Cell Cycle.- 4. p16 Family Inhibitors of Cyclin-Dependent Kinases.- 5. p53-Mediated Apoptosis: Regulatory and Mechanistic Aspects.- 6. The Molecular Genetics of Wilms Tumor.- 7. HTLV-I Tax: A Paradigm for How a Single Auxiliary Factor Can Regulate the Expression of Viral and Cellular Genes.- 8. CREM: Transcriptional Pacemaker of the cAMP Response.- 9. MADS-Domain Transcription Factors and Their Accessory Proteins (TCFS): Nuclear Targets for Growth Control Signals.- 10. Retinoblastoma Protein, Gene Expression, and Cell Cycle Control.- 11. Cyclin A-Kinase Binding to and Regulation of the Function of a Growth-Promoting Transcription Factor.- 12. Homeostatic Mechanisms Governing the Go Phase as Defined by the gas Genes.- 13. The Tel Gene and Human Leukemias.- 14. Characterization of the TCLI Gene and Its Involvement in T-Cell Malignancies.- 15. Targeting Ubiquitin-Mediated Degradation for Proliferation Inhibitors.- 16. Selective Killing of BCR-Abl Positive Cells with a Specific Inhibitor of the Abl Tyrosine Kinase.- 17. Unexpected Functions of Granulocyte-Macrophage Colony Stimulating Factor.