The study and therapeutic application of macrophages is a rapidly developing field. Tremendous progress has been made in understanding the phenotypes and functions of macrophages in healthy and diseased tissues and organs.

Following the great success of Volume 62: "Macrophages - Origin, Functions and Biointervention" published in this series, this new book now focuses on the role of monocytes and macrophages in development, regeneration and disease. This new volume offers an overview of the latest developments in monocyte and macrophage subtypes and functions across various tissues including adipose tissue, bones, liver, lungs, testes, and the nervous system.

The book also reviews existing and potential therapies targeted towards the macrophages and describes their homeostatic functions. It explores how macrophage cell cycle, metabolism, mitochondrial activity, histone acetylation status, and interaction with the extracellular matrix contribute to changes in macrophage phenotype and function in health and disease. Additionally, it examines the interactions between macrophages and cancer cells, bacteria, helminth parasites, and their role in the colonization and spread of HIV.

For ease of reference, the volume is divided into three sections:

• Part I Nonimmunologic and immunologic functions of monocytes/macrophages
• Part II Tissue/organ specific functions of macrophages
• Part III Macrophage functions and dysfunction in diseases
  This book will be of interest to researchers working in the fields of developmental biology, immunology, cancer research, and therapeutic applications. It is written to inform and inspire experts and newcomers to the field of macrophages.

Gives a state-of-the-art overview on monocyte/macrophage functions Discusses the role of monocytes/macrophages in development, regeneration, and disease Reviews existing and potential therapies targeted towards the macrophages

Autorentext

Dr. Malgorzata Kloc: Prior to completing her postdoctoral training in Canada, Dr. Kloc was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc joined the Houston Methodist Research Institute in 2008. Currently, Dr. Kloc is the Weill Cornell Professor of Cell and Molecular Biology at The Houston Methodist Hospital and the Adjunct Professor at Department of Genetics, University ofTexas, M D Anderson Cancer Center.

Dr. Jacek Z. Kubiak is the Research Director (Professor) at the French National Research Institute CNRS in Rennes, France. His research is devoted to molecular mechanisms of early embryo development, cell cycle regulation, stem cells, cancer cells and the role of macrophages in the innate immune response. He is the author of over 180 highly cited scientific articles and the editor or co-editor of 10 books. He has graduated from the Warsaw University, Poland and worked at the University of Wisconsin-Madison, USA, Marine Biological Laboratory in Woods Hole, USA and in Jacques Monod Institute in Paris, France. He collaborates with research institute WIM-PIB in Warsaw, Poland combining stem cells, wound healing and cancer research with the prospective in medical applications. Since the COVID-19 outbreak, he co-ordinates an international research group focused on SARS-CoV-2 infection in paediatric patients and he follows up this research field.

Marta Halasa earned her PhD in medical and health science from the Medical University of Lublin, Poland, in 2022. Her research during her doctoral studies focused on epigenetic modifiers, particularly histone deacetylases, and their impact on cancer progression and metastasis. During her PhD, she completed a long-term internship at the University of Turku, Finland, where she gained expertise in 3D cell techniques. She also undertook an internal internship at the Military Institute of Medicine in Warsaw, Poland, where she investigated cell-gene therapy in Alzheimer's disease. After completing her PhD, she obtained a postdoctoral fellow position at the Houston Methodist Research Institute, USA. Currently, her research focuses on investigating the role of macrophages in chronic transplant rejection.

Inhalt

Part I Nonimmunologic and Immunologic Functions of Monocytes/Macrophages.- Chapter 1 Homeostatic Functions of Tissue-Resident Macrophages and Their Role in Tissue Maintenance.- Chapter 2 Macrophages and the Extracellular Matrix.- Chapter 3 Immunometabolic Rewiring: A Tale of Macronutrients and Macrophages.- Chapter 4 Macrophage Cell Cycle.- Part II Tissue/Organ Specific Functions of Macrophages.- Chapter 5 Origin and Role of Testicular Macrophages in Testis Development, Steroidogenesis, and Spermatogenesis.- Chapter 6 Adipose Tissue Macrophages.- Chapter 7. Liver Macrophage Diversity in Health and Disease.- Part III Macrophage Functions and Dysfunction in Diseases.- Chapter 8 Crosstalk Between Macrophages and Breast Cancer Cells: Networking Within Tumors.- Chapter 9 Macrophage Dysfunction in Respiratory Disease.- Chapter 10 Macrophages in Lung Repair and Fibrosis.- Chapter 11 Macrophage Polarization and Its Impact on Osteoporosis.- Chapter 12 Unlocking Macrophage Secrets: Histone Deacetylases in Chronic Transplant Rejection.- Chapter 13 Monocytes/Macrophages in Helminth Infections: Key Players in Host Defence, Inflammation, and Tissue Repair.- Chapter 14 Macrophages, Metabolism, Mitochondria, Circadian Rhythmicity and the Pathogen: the Multidimensional Nature of Tuberculosis.- Chapter 15 Role of Monocyte/Macrophages in the Pathogenesis of NeuroHIV.