This volume contains the proceedings of an International Sympo sium on the Biology and Pharmacology of Tumor Cell Differentiation held on June 29-July I, 1986 at the University of Tromso, Norway. The objective of this meeting was to bring together scientists from various disciplines to discuss recent advances in the understanding of tumor cell differentiation and to bridge the gap between experimental findings and clinical application of new knowledge. Thus the infor mation will be of value not only to basic scientists involved in mol ecular and cell biology, but also to pharmacologists and clinicians trying to develop the concept of tumor cell differentiation as a thera peutic modality. Each plenary speaker and selected poster presenters were requested to submit a comprehensive, up-to-date review of recent contributions to their disciplines related to differentiation and: hematopoietic factors and leukemic cells in culture~ vitamin deriva tives and polyamines; nucleosides and methylation; and cell interac tions.

Klappentext

This work offers insights into the biology and pharmacology of tumour cells. Researchers and clinicians from many parts of the world present information on a wide variety of topics.

Inhalt
Hematopoietic Factors, Leukemic Cells in Culture, and Differentiation.- Hematopoietic Growth and Differentiation Factors and the Reversal of Malignancy.- G-CSF as a Differentiation-Inducing Agent in Normal and Leukemic Myelopoiesis.- Induction of Differentiation in Myeloid Cells and the Differentiation Inducing Factor (DIF).- Proliferation and Differentiation of Human Leukemic Cells in Culture.- Infrequent Phenotypes of Clonogenic Cells in AML: Evidence for Abnormal Differentiation and Possibilities for Detecting Minimal Disease?.- Studies of Gene Expression During Granulocyte Maturation.- Granulocytes Obtained from HL-60 Cells by Retinoic Acid Treatment Behave Abnormally in Hematopoietic RegulationPossible Consequences for Differentiation Induction Treatment of Leukemia.- 115 Beta-Adrenergic Receptors of Normal, Transformed, and Immature Human Leucocytes.- Vitamin Derivatives, Polyamines, and Differentiation.- Molecular and Cellular Aspects of Embryonal Carcinoma Cell Differentiation.- Interaction of 1,25-Dihydroxy vitamin D3 with Normal and Abnormal Hematopoiesis.- Retinoic Acid-Induced Differentiation of HL-60: Studies in Vitro and in Vivo.- Plasma Membrane Signals Linked to the Retinoic Acid-Induced Differentiation of HL-60 Cells.- Does Induction of Differentiation Have a Role in the Maintenance of Remission in Acute Myelogenous Leukemia in Children?.- Therapeutic Effects of Low-Dose Cytosine Arabinoside, ?-Interferon, 1,25-Dihydroxyvitamin D3, Retinoic Acid in Myelodysplastic Syndromes and Acute Leukemia.- Nucleosides, Methylation, and Differentiation.- Sequence-Specific DNA Methylation: Promoter Inactivation and Release of the Expression Block.- Induction of Differentiation of 3T3-L1 Fibrolasts to Adipocytes by 3-Deazaadenosine and Insulin.- Differentiation ofHuman Leukemia Cells by Nucleoside Analogues.- Effects of Purine Nucleosides on Differentiation in Lymphohematopoietic Stem Cell Leukemia.- Effects of Methylation Inhibitors on Phorbol Ester-Induced Differentiation of HL-60 Promyelocytic Leukemia Cells.- Perturbation of Homocysteine Metabolism by Pharmacological Agents in Experimental and Clinical Use.- C-8-Substituted Guanosine Analogues Are Novel Immunostimulants and Differentiating Agents for Neonatal, Normal, and X-Linked Immune Defective (xid) B Lymphocytes.- Cell Interactions and Differentiation.- Differentiation as a Mechanism for Control of Malignancy in Human Cell Hybrids.- Interaction Between Brain Tissue and Malignant Glioma Cells in Organ Culture.- Tumor Promoter-Mediated Modulation of Cell Differentiation and Communication: The Phorbol Ester-Oncogene Connection.