This volume explores various aspects of reversible acetylation of histone and non-histone proteins, focusing on their roles in development, ageing and disease progression.

It examines the biological consequences of modulating acetylation levels by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Covered are manipulations at multiple levels, from in vitro and in vivo studies to clinical trials and FDA-approved therapies.

The book is divided in four parts:

• Part I provides an overview of post-translational modifications in the context of development, ageing, neurodegenerative and cancer-related diseases. It highlights the role of histone acetylation in higher genome organization and explores the functions of the proteins involved.
• Part II focuses on the modulation of cytoskeleton-associated proteins through reversible acetylation. It examines how acetylation influences cytoskeletal compartments, thereby regulating cellular structure and function.
• Part III examines acetylation in the context of development. It describes acetylation as a key regulator of early embryogenesis, influencing chromatin structure and gene expression.
• Part IV discusses physiological and pathological aspects of histone and non-histone protein acetylation and its modulation by activators and inhibitors.
  The book is a valuable resource for scientists, clinicians and academic teachers alike.

A comprehensive overview on reversible acetylation of histone and non-histone proteins Discusses the role of reversible acetylation in development, aging, and disease progression Highlights progress in the development of selective inhibitors and their potential use in the clinic

Autorentext

Marta Halasa earned her PhD in medical and health science from the Medical University of Lublin, Poland, in 2022. Her research during her doctoral studies focused on epigenetic modifiers, particularly histone deacetylases, and their impact on cancer progression and metastasis. During her PhD, she completed a long-term internship at the University of Turku, Finland, where she gained expertise in 3D cell techniques. She also undertook an internal internship at the Military Institute of Medicine in Warsaw, Poland, where she investigated cell-gene therapy in Alzheimer's disease. After completing her PhD, she obtained a postdoctoral fellow position at the Houston Methodist Research Institute, USA. Currently, her research focuses on investigating the role of macrophages in chronic transplant rejection.

Anna Wawruszak got her PhD at the Department of Biochemistry and Molecular Biology at the Medical University in Lublin, Poland, in 2020. Since then, she has been working at the Medical University of Lublin as a postdoc, researcher and, finally, an Associate Professor. Her primary expertise lies in translational medicine, epigenetics and breast cancer research. Her work is mainly focused on the anti-cancer activity of histone deacetylase inhibitors in breast cancer models. She has also an interest in green chemistry and biotechnology approaches for the development of nature-based cosmetics.

Inhalt

Part I. Introduction to Reversible Acetylation and Its Biological Consequences .- Chapter 1. Histone and Non-Histone Reversible Acetylation in Development, Aging and Disease.- Chapter 2. Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer.- Part II. Acetylation of Cytoskeleton-Associated Proteins .- Chapter 3. Acetylation and Deacetylation of Cytoskeleton-Associated Proteins.- Chapter 4. Tubulin Acetylation: A Critical Regulator of Microtubule Function.- Chapter 5. Tubulin Acetylation and the Cellular Mechanosensing and Stress Response.- Part III. Acetylation in Development .- Chapter 6. Reversible Histone Acetylation During Preimplantation Embryo Development in Mammals.- Chapter 7. Epigenetic Echoes: Decoding the Acetylation Journey from Neural Crest to Melanocyte.- Part IV. Acetylation in Physiological and Pathological Processes .- Chapter 8. Impact of Histone Acetyltransferases and His-tone Deacetylases on Adult Brain Myelin Plastici-ty.- Chapter 9. Acetylation in Cardiac Aging: Molecular Mechanism and Therapeutic Approaches.- Chapter 10. Regulatory Roles for SIRT1 in Aging and Immunosenescence.- Chapter 11. Repurposing Histone Deacetylase Inhibitors for Management of Solid Organ Transplant Rejection.- Chapter 12. Acetylation in Viral Infection and Disease.- Chapter 13. Reversible Acetylation of Non-Histone Proteins in Human Cancers.- Chapter 14. Lysine Acetyltransferase 6 Complexes in Neurodevelopmental Disorders and Different Types of Cancer.- Chapter 15. Bromodomain and PHD Finger-Containing Protein 1: From Biological Functions to a Developmental Disorder, Cancer and Therapeutics.