The Annexins is focused on a specific family of calcium and membrane-binding proteins, annexins, ubiquitously spread within living organisms, including animals, plants and fungi. The volume covers important areas of annexinology. The characterization of structural-functional relationship within the annexin family of proteins, together with emerging transgenic animal models, provides an up-to-date overview of potential physiological roles of annexins. Growing evidence of participation of annexins in human diseases, called annexinopathies, related to disturbances in signal transduction, vesicular traffic, ion homeostasis and energy metabolism within the cell.
The book will attract a broad scientific audience, not only scientists interested in annexins, but also others involved in multidisciplinary studies, as well as undergraduate and postgraduate students. It can be used in courses relating to special topics such as calcium homeostasis, calcium-binding proteins, membrane structure and transport properties, various signal transduction pathways, and membrane trafficking.

Inhalt
Preface; J. Bandorowicz-Pikula. Structure, function and evolution of the annexin gene superfamily; M.P. Fernandez, R.O. Morgan. Structural conservation and functional versatility: allostery as a common annexin feature; A. Hofmann, R. Huber. Self-assembly of Annexin A5 on lipid membranes; N. Govorukhina, W. Bergsma-Schutter, C. Mazères-Dubut, S. Mazères, E. Drakopoulou, L. Bystrykh, F. Oling, A. Mukhopadhyay, I. Reviakine, J. Lai Kee Him, A. Brisson. Annexin gene knock-out models; A. Tomas, M.J. Hayes, D. Roy, B. Young, S.E. Moss. Annexin V: stimulation-dependent association with membrane protein; E. Tzima, J.H. Walker. Annexin 1 crystal structure interaction of annexins with membranes; A. Rosengarth, H. Luecke. Annexin II heterotetramer analysis of a pleiotropic protein; N.R. Filipenko, D.M. Waisman. Role of annexin VI in receptor-mediated endocytosis, membrane trafficking and signal transduction; T. Grewal, C. Enrich, S. Jackle. Annexins and tissue mineralization matrix vesicles, ion channel activity of annexins and annexin V/collagen interactions; T. Kirsch. Acidic pH-induced ion channels formed by annexin VI transformation from soluble to membrane integral protein; S. Pikula. Annexinopathy in the antiphospholipid syndrome; J.H. Rand, Xiao-Xuan Wu. Annexins and phospholipases; A.G. Buckland, D.C. Wilton. Role of annexin II tetramer in the regulation of plasmin activity; Kyu-Sil Choi, D.K. Fogg, S. Fitzpatrick, D.M. Waisman. The nucleotide face of annexins; J. Bandorowicz-Pikula. Involvement of human annexins in viral entry; E. Depla.