In vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain.
This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.

Inhalt

Preface.
1. Evolution of Integrin I-Domains; *M.S. Johnson, D. Tuckwell.*
2. Integrin alpha1beta1; *H. Gardner.*
3. Function of alpha2beta1 Integrin; M.M. Zutter, *S.A. Santoro.*
4. Structure Distribution and Function of alpha10beta1 Integrin; E. Lundgren-Åkerlund, M. Schneller. 5. Structure and Function of alpha11beta1 Integrin; D. Gullberg, S.N. *Popova, C.-F. Tiger.*
6. Structure and Activation of beta2-Integrins; *C.G. Gahmberg, S. Fagerholm.*
7. Integrin alphaEbeta7: Molecular Features and Functional Significance in the Immune System; *P.J. Kilshaw, J.M.G. Higgins.*
8. Structural Aspects of Integrins; *R.C. Liddington.*
9. Integrin Recognition Motifs in Collagens; *R.W. Farndale.*
10. Cellular Signaling by Collagen-Binding Integrins; *J. Heino.*
11. Collagen-Binding Integrins and Disease; *B. Eckes, B. Nieswandt, T. Krieg.*
12. Integrins in Immune and Inflammatory Disease; A.R. de Fougerolles. 
Index.