This book examines every major aspect of Alzheimer's disease (AD). It provides exciting, comprehensive and up-to-date summaries of the most important recent advances in the genetic, molecular, biochemical, and cell biological studies of AD. There has been no scholarly research volume on AD published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins. Treatment of symptoms with therapeutic drugs is discussed, along with outcomes of and problems inherent in clinical trials for AD. The studies and advances described in this volume will help to accelerate the process of rational drug discovery and soon serve to extend and enhance the mental health and lifespan of our burgeoning elderly population.

There has been no scholarly research volume on Alzheimer's Disease published in the last 3-5 years The editors are leaders in the field and have assembled many other leading researchers as contributors Includes supplementary material: sn.pub/extras

Inhalt
The Genetics of Alzheimer's Disease.- APP Biology, Processing and Function.- The Biology of the Presenilin Complexes.- ?-secretase: Physiological Role and Target Validation.- Cognitive Impairment in Transgenic A? and Tau Models of Alzheimer's Disease.- Cholesterol and ?-Amyloid.- A? Structure and Aggregation.- Signaling Mechanisms that Mediate A? Induced Neuronal Dysfunction.- Beta Amyloid and Excitatory Synapses.- A? Degradation.- Role of A ? Transport and Clearance in the Pathogenesis and Treatment of Alzheimer's Disease.- Tau Gene Mutations in FTDP-17 Syndromes.- Animal Models of Tauopathy.- Tau and Axonal Transport.- Growth Factors in Alzheimer's Disease.