The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts in their field, Musculoskeletal Tissue Regeneration: Biological Materials and Methods aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. On the cusp of a revolution, musculoskeletal repair is based on new tools that have recently become available or are about to emerge into clinical practice. By their very nature, these tools require an interdisciplinary approach, utilizing teams comprised of surgeons, engineers, and scientists in collaboration between industry and academia. A valuable resource for researchers, developers, and clinicians, Musculoskeletal Tissue Regeneration: Biological Materials and Methods presents a foundation to propel the technology and integration of the current state of knowledge into the twenty-first century.

Zusammenfassung
Tissue engineering and regenerative medicine will ultimately have a more profound impact than most of us can fully appreciate. The combination of the principles of engineering with advances in the material sciences, and an increased understanding of developmental biology has the potential to influence developments in medicine and biotechnology more than any single advance in these fields during the last several decades. I would first like to applaud the volume editor, Dr. Pietrzak, and the authors for their efforts in bringing together a group of interrelated topics to create a textbook emphasizing the Tissue Engineered generation of musculoskeletal tissue. The authors of this book are all established experts in their respective fields. The publication of a separate volume dedicated to musculoskeletal tissue regeneration as part of a series focusing on orthopedic biology and medicine is a reflection of the tremendous growth of knowledge and ongoing developments that have occurred in this field over the last decade. Musculoskeletal Tissue Regeneration: Biological Materials and Methods is intended to cover the basic fundamentals and early treatment of musculoskeletal disease, tissue loss and wound healing, as well as provide a comprehensive summary of recent advances in regenerative medicine and tissue engineering as they relate to the musculoskeletal system, and should serve as a reference for researchers and graduate students in this discipline.

Inhalt
Background.- Musculoskeletal and Wound Treatment Through the Ages: A Brief Historical Tour.- Musculoskeletal Fundamentals: Form, Function, and a Survey of Healing Strategies.- Overview of Fracture Repair.- Hard Tissue Technologies.- Autograft Bone.- Biology of Bone Allograft and Clinical Application.- Demineralized Bone Matrix: Maximizing New Bone Formation for Successful Bone Implantation.- Deproteinized Bovine Bone Xenograft.- Bioactive Bioceramics.- Distraction Osteogenesis of the Orthopedic Skeleton: Basic Principles and Clinical Applications.- Distraction Osteogenesis of the Facial Skeleton.- Bone Morphogenetic Proteins and Other Bone Growth Factors.- Biological Approaches to Spinal Fusion.- Electrical Bone Stimulation.- Soft Tissue Technologies.- Meniscus Repair Techniques.- Lessons Learned From Our First 100 Meniscus Allograft Transplants in Arthritic Knees.- Tissue Engineering of the Meniscus.- Osteochondral Grafts.- Autologous Chondrocyte Cartilage Repair.- Autograft and Allograft ACL Reconstruction: Construct Rationale.- Tissue Engineered Anterior Cruciate Ligament Graft.- Biologic Scaffold Materials for Orthopaedic Soft Tissue Reconstruction.- Muscle Repair after Injury and Disease.- Generalized Approaches.- Principles of Musculoskeletal Tissue Banking.- Bioabsorbable Polymer Applications in Musculoskeletal Fixation and Healing.- Tissue Adhesives: Science, Products, and Clinical Use.- Platelet-Rich Plasma in Orthopedics.- Gene Therapy Approaches for Musculoskeletal Tissue Regeneration.- Paradigms of Tissue Engineering with Applications to Cartilage Regeneration.- The Future.- The Future of Musculoskeletal Tissue Regeneration: A Clinical Perspective.