The increasing incidence of diabetes worldwide has prompted a rapid growth in the pace of scientific discovery and clinical understanding of this enigmatic disease. In Type 1 Diabetes: Etiology and Treatment, well-recognized physicians and researchers review the latest thinking about the causes of this condition and the best approaches to treating both its acute and chronic complications. The treatment options discussed range from life-threatening diabetic ketoacidosis to contemporary insulin regimens, from open- and closed-loop insulin delivery devices to modern glucose-sensing mechanisms, as well as such daily life issues as nutrition and education. Also discussed are the management of children under the age of five, the special problems of preadolescents and adolescents, diabetic surgery, and pregnancy, along with the treatment and prevention of the long-term vascular complications that produce coronary artery disease, the loss of limbs, end-stage renal disease, and blindness. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.
Authoritative and up-to-date, Type 1 Diabetes: Etiology and Treatment provides all those caring for diabetic patients with a concise, accessible survey of today's best thinking about the causes, treatment, and management of this complex disease.

Klappentext

A concise survey by physicians and researchers of the latest thinking about the causes of diabetes and the best approaches to treating its acute and chronic complications. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.

Inhalt

I. Etiology Epidemiology of Type 1 Diabetes Janice S. Dorman, Ronald E. LaPorte, and Thomas J. Songer Genetics of Type 1 Diabetes Massimo Pietropaolo and Massimo Trucco Prediction and Prevention of Type 1 Diabetes Aristides K. Maniatis and George S. Eisenbarth Molecular Biology of b-Cell Destruction by Autoimmune Processes Åke Lernmark and Choon Hee Chung Type 1 Diabetes in Autoimmune Syndromes Tiinamaija Tuomi and Jaakko Perheentupa The Metabolic Basis of Insulin Secretion Nicolai M. Doliba and Franz M. Matschinsky Prevention and Correction of Hypoglycemia: Relevance to Type 1 Diabetes Philip E. Cryer Nonautoimmune Forms of Diabetes: Neonatal Diabetes, DIDMOAD-Wolfram Syndrome, and Related Syndromes Timothy G. Barrett II. Treatment of Type 1 Diabetes Diabetic Ketoacidosis Ram K. Menon and Mark A. Sperling Insulin Regimens for Type 1 Diabetes Baiju R. Shah and Bernard Zinman Relationship Between Metabolic Control and Complications in Diabetes: Therapeutic Implications of the Diabetes Control and Complications Trial Saul Genuth Open- and Closed-Loop Insulin Delivery Systems and Glucose Sensors John C. Pickup Living with Diabetes: Educating the Patient and Family with Type 1 Diabetes Jean Betschart Roemer and Linda Siminerio Nutritional Management in Type 1 Diabetes Christine A. Beebe III. Special Management Issues in Type 1 Diabetes Special Problems and Management of the Child Less than 5 Years of Age Nadia Tubiana-Rufi and Paul Czernichow The Preadolescent Child with Type 1 Diabetes William V. Tamborlane, Elizabeth A. Boland, and Margaret Grey The Adolescent with Type 1 Diabetes George A. Werther, Fergus J. Cameron, and John M. Court Hypoglycemia in Type 1Diabetes Stephanie A. Amiel and Krystyna Matyka Pregnancy and Type 1 Diabetes Erica M. Sommermann, Erin K. Van Meter, and Lois Jovanovic Surgery for the Patient with Type 1 Diabetes Adrian Vella and Robert A. Rizza IV. Long-Term Complications of Type 1 Diabetes Biochemistry and Molecular Biology of Diabetic Complications Kenya Sakamoto and Michael Brownlee The Eye: Diabetic Retinopathy/Ophthalmopathy David Kent and Peter A. Campochiaro The Kidney: Diabetic Nephropathy Abhay Vats and Frederick DeRubertis Diabetic Peripheral and Autonomic Neuropathy Eva L. Feldman, Martin J. Stevens, and James W. Russell The Diabetic Foot David L. Steed Atherosclerosis in Type 1 Diabetes Wael Emad Eid, Siripoom McKay, Finnbogi Karlsson, and Alan J. Garber Cutaneous Complications of Type 1 Diabetes Jean L. Bolognia and Irwin M. Braverman Infection and Diabetes Nirmal Joshi Pancreas Transplantation R. Paul Robertson Islet Transplantation Thierry Berney, Norma Sue Kenyon, Rodolfo Alejandro, Luca Inverardi, Daniel H. Mintz, and Camillo Ricordi b-Cell Replacement Therapy for Type 1 Diabetes Shimon Efrat Islet Growth Factors Rupangi C. Vasavada, Adolfo Garcia-Ocaña, Karen K. Takane, Ana Cebrian, Juan Carlos Lopez-Talavera, and Andrew F. Stewart Index