Key workers in vascular medicine and biology apply state-of-the-art techniques in cell and molecular biology to study the endothelial and vascular smooth muscle cells. The distinguished scientists and clinicians open a new area of endocrinology, which sees the vasculature and kidney as endocrine organs and sheds new light on the hormonal regulation of the cardiovascular system. They also add significantly to our current understanding of the autocrine, paracrine, and endocrine regulation of vascular function in health and in those vascular disease states that accompany diabetes mellitus, dyslipidemia, and hypertension. Endocrinology of the Vasculature is the first book to comprehensively and systematically explore the vasculature as an endocrine organ.

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Part I. The Endothelium. Endothelium-Derived Relaxing Factor: An Overview, John P. Cooke and Philip S. Tsao. Ionic Mechanisms of Peptide-Induced Responses in Vascular Endothelial Cells, Jianben Song and Jeffrey L. Ram. Non-cGMP, Paracrine Effects of Nitric Oxide in the Vasculature, Nancy L. Kanagy, Rajabrata Sarkar, Stephanie W. Watts, and R. Clinton Webb. The Endothelin Peptides: Roles in Physiology and Pathophysiology, Ellis R. Levin. Estrogen and Vascular Reactivity, Marie D. Gerhard and Mark A. Creager. C-Type Natriuretic Peptide: The Vascular Component of the Natriuretic Peptide System, Iftikhar J. Kullo and John C. Burnett, Jr. Vascular Actions of Insulin in Health and Disease: Role of the Endothelium, Alain D. Baron and Helmut O. Steinberg. Angiotensin-Nitric Oxide: Interaction and the Regulation of Renal Vascular Tone, William H. Beierwaltes and David H. Sigmon. Altered Endothelial Function in Diabetes Mellitus: An Overview, Richard L. Klein and John A. Colwell. Vascular Abnormalities in Diabetes Mellitus, Katherine D. Hein and George L. King. Effects of Hyperglycemia on Vascular Endothelium Nitric Oxide Metabolism, Steven B. Magill and Jamie Dananberg. Evidence Linking Fatty Acids, the Risk Factor Cluster, and Vascular Pathophysiology: Implications for the Diabetic Hypertensive Patient, Brent M. Egan and Konrad T. Stepniakowski. Effects of Low Density Lipoproteins on Endothelial Cell Signaling and Adhesion Molecule Expression, Hermann Haller and Friedrich C. Luft. Part II. Vascular Smooth Muscle Cells. Angiotensin II Signal Transduction in Vascular Smooth Muscle, Bradford C. Berk, Jennifer L. Duff, Mario B. Marrero,and Kenneth E. Bernstein. The Vascular Renin System, Peter Eggena and Jack D. Barrett. Effects of Insulin on Vascular Smooth Muscle Contraction, Andrew M. Kahn and Tom Song. Sex Hormones and the Vasculature, Suzanne Oparil, Ronald L. Levine, and Yiu-Fai Chen. Vitamin D and the Vessel Wall, Richard D. Bukoski. Vascular Action Natriuretic Peptide Receptors, Kailash N. Pandey. A Novel Vascular Hormone: Adrenomedullin, Willis K. Samson. Calcium and Magnesium in the Regulation of Smooth Muscle Function and Blood Pressure: The Ionic Hypothesis of Cardiovascular and Metabolic Diseases and Vascular Aging, Mario Barbagallo and Lawrence M. Resnick. Regulation of Intracellular pH and the Na+/H+ Antiporter in Vascular Smooth Muscle, Michael S. LaPointe and Daniel Batlle. Endocrine Regulation of Vascular Smooth Muscle Intermediary Metabolism, Ligia J. Dominguez, Jacob D. Peuler, and James R. Sowers. Analogy Between Endothelial/Mesangial Cell and Endothelial/Vascular Smooth Muscle Cell Interactions: Role of Growth Factors and Mechanotransduction, George L. Bakris, Paul R. Standley, Carlos E. Palant, Mary F. Walsh, and James R. Sowers. Arachidonic Acid Metabolites in the Vasculature, Michael S. Golub, Mark T. Hori, and Michael L. Tuck. Arachidonic Acid Metabolites on Renin and Vascular Smooth Muscle Cell Growth, Rama Natarajan, Naftali Stern, and Jerry Nadler. Index.