Tumor Virus-Host Cell Interaction

The oncogenic virus can only be studied as a carcinogen when its relation to the host cell in which it resides is understood. The interaction between tumor virus and host cell was the subject of a recent North Atlantic Treaty Organization Advanced Study I~stitute. This volume is the edited proceedings of this study institute. One problem of fundamental importance in understanding malignant transformation is the mechanism by which the oncogenic vector promotes the aberrations in the host cell regulatory appara­ tus resulting in a cancerous cell. It is partly the purpose of this volume to help clarify this problem, and to stimulate the interest of others to continue the research necessary to this end. The meeting from which this volume is compiled took place in the Principality of Monaco with the patronage of Her Serene High­ ness, Princess Grace and was supported principally by a grant from the North Atlantic Treaty Organization. The editor wishes to thank the North Atlantic Treaty Organization, Princess Grace of Monaco, and the Bureau de Tourism Monaco for their generous support. Addi­ tional financial assistance was provided by the Deutsches Studium Gesellschaft and I would like to thank Prof. Klaus Munk, Deutsches Krebsforschungszentrum, for his help in obtaining this aid. I would also like to thank the Verwaltung of the Deutsches Krebsfor­ schungszentrum for their administrative help.

Inhalt

Knowledge and Ignorance about the Molecular Biology of Small Oncogenic DNA Containing Viruses.- Studies of SV40 DNA Replication.- An Analysis of the Structure of the Replicating Fork during Discontinuous Synthesis of SV40 DNA and the Detection of Gap Circle Intermediates.- The Repeated Sequences in Serially Passaged SV40 DNA.- Some Properties of Superhelical Oligomeric and Integrated SV40 DNA Sequences.- Simian Virus 40 in Synchronized Monkey Cells: Integration of Viral DNA into the Cell Genome and Timing of Replication.- Transcription of SV40 in Lytically Infected and Transformed Cells.- The Structural Proteins of SV40 and Polyoma Virus.- The Cell Free Translation of Purified Simian Virus 40 Messenger RNA.- Studies on Non-Transforming Host Range Mutants of Polyoma Virus.- The Properties of a Polyoma Virus Mutant, ts3.- Intracellular Forms of Adenovirus DNA in Productively Infected Cells: Evidence for Integration of the Viral Genome.- The Mechanism of Replication of Adenovirus Type 5 DNA.- The Isolation and Characterization of DNA Binding Proteins Specific for Adenovirus Infected Cells.- Adenovirus DNA: Transcription during Productive Infection, Integration in Transformed Cells, and Replication in Vitro.- Characterization and Metabolism of Nuclear Viral RNA Synthesized 18 Hours after Infection with Adenovirus 2.- The Provirus of Rous Sarcoma Virus: Synthesis, Integration and Transcription.- Temperature-Sensitive DNA Polymerase from Rous Sarcoma Virus Mutants.- Mechanism of Inhibition of RNA Tumor Virus Reverse Transcriptase by Rifamycin SV Derivatives.- Cell Surface Antigens in Oncornavirus Transformed Cells.- Stability of Avian Oncornavirus Precursor Protein in a Line of RSV-Transformed Hamster Cells.- Comparative Studies on the Molecular Basis for a Viral Involvement in Murine and Human Mammary Adenocarcinoma.- Use of Pseudotypes of Vesicular Stomatitis Virus to Study Cellular Resistance to Murine RNA Tumor Viruses.- Human Acute Leukemia: Increasing Evidence for Involvement of Type-C RNA Tumor Viruses.- Herpes Simplex Virus: Aspects of Structure and Regulation of Viral RNA and Protein Synthesis.- Malignant Transformation by Herpesviruses.- Recognition of Virus Genomes in Cells by Molecular Hybridization.- The Characterization of an in Vitro Isolated Nuclei System for the Investigation of the Mechanism of Herpesvirus DNA Replication in Infected Human Embryonic Lung Cells.- Participants.