This book constitutes extended, revised and selected papers from the 22nd International Conference on Enterprise Information Systems, ICEIS 2020, held online during May 5-7, 2020.The 41 papers presented in this volume were carefully reviewed and selected for inclusion in this book from a total of 255 submissions. They were organized in topical sections as follows: database and information systems integration; artificial intelligence and decision support systems; information systems analysis and specification; software agents and internet computing; human-computer interaction; and enterprise architecture.