Although much work remains to be done toward understanding the causes of schizophrenia and attenuating its symptoms, a clear consensus has emerged that better outcomes are associated with early treatment. In Early Clinical Intervention and Prevention in Schizophrenia, leading and internationally recognized researchers review what is known about the liability to schizophrenia, how it progresses, what it looks like clinically-with an emphasis on a specific (proposed) syndrome of liability (schizotaxia)-and how best it might be treated now and in the near future. The authors summarize the latest findings on the genetic, early environmental, and neurodevelopmental origins of schizophrenia, and detail the nature of the vulnerability to schizophrenia from several perspectives, including the prodrome and their proposed pre-prodromal syndrome of schizotaxia. Specific factors, such as cognitive deficits in high-risk populations, neuroanatomical abnormalities, and psychophysiological deficits are also considered. From this material, the contributors develop protocols for the treatment of schizotaxia and prodromal symptoms, and discuss issues related to genetic counseling. They also explore the neurochemical and molecular possibilities for advancing the goals of prevention and early intervention in schizotaxia.
Timely and cutting-edge, Early Clinical Intervention and Prevention in Schizophrenia offers psychologists, psychiatrists, and neurologists an authoritative account of how the liability to develop schizophrenia is expressed in meaningful, measurable ways that can provide a basis for early intervention and preventive efforts.

Klappentext

Leading and internationally recognized researchers review what is known about the liability to schizophrenia, how it progresses, what it looks like clinically-with an emphasis on a specific (proposed) syndrome of liability (schizotaxia)-and how best it might be treated now and in the near future. The authors summarize the latest findings on the genetic, early environmental, and neurodevelopmental origins of schizophrenia.

Inhalt

Part I. The Etiology and Genetics of Schizophrenia The Genetic Basis of Schizophrenia Stephen V. Faraone, Stephen J. Glatt, and Levi Taylor Early Environmental Determinants of Schizophrenia Jason Schiffman, John Carter, Ricardo A. Machón, and Sarnoff Mednick Obstetric Risk Factors for Schizophrenia and Their Relationship to Genetic Predisposition: Following Ariadne's Double-Stranded Thread Through Early Development Stefano Marenco and Daniel R. Weinberger Part II. The Vulnerability to Schizophrenia The Nature of the Prodrome in Schizophrenia Jaak Rakfeldt and Thomas H. McGlashan The Nature of Schizotaxia Stephen V. Faraone, Ming T. Tsuang, and Sarah I. Tarbox A Neuropsychological Perspective on Vulnerability to Schizophrenia: Lessons From High-Risk Studies Allan F. Mirsky and Connie C. Duncan Neurocognitive Deficits in the Biological Relatives of Individuals With Schizophrenia William S. Kremen and Anne L. Hoff The Nature and Origin of Socioemotional Deficits in Schizophrenia Elaine Walker and Karen M. Hochman Neuroimaging Studies of Nonpsychotic First-Degree Relatives of People With Schizophrenia: Toward a Neurobiology of Vulnerability to Schizophrenia Larry J. Seidman, Heidi E. Wencel, Colm McDonald, Robin M. Murray, and Ming T. Tsuang Neurophysiological Endophenotypes in Early Detection of Schizophrenia Marina Myles-Worsley Is the Development of Schizophrenia Predictable? Paola Dazzan, Eugenia Kravariti, Paul Fearon, and Robin M. Murray Part III. Early Intervention and Prevention of Schizophrenia Prevention of Schizophrenia and Psychotic Behavior: Definitions and Methodological Issues C. Hendricks Brown and Stephen V. Faraone The Treatment of Schizotaxia Ming T. Tsuang, Sarah I. Tarbox, Levi Taylor, and William S.Stone Treatment of the Schizophrenia Prodrome Barbara Cornblatt, Todd Lencz, Christopher Smith, and Andrea Auther The Role of Genetic Counseling Debby W. Tsuang, Stephen V. Faraone, and Ming T. Tsuang Part IV. Challenges for the Near Future The Biology of Schizotaxia William S. Stone, Stephen J. Glatt, and Stephen V. Faraone Molecular Medicine and the Prospects for Prevention and Early Intervention in Schizophrenia William T. Carpenter, Jr. and James I. Koenig Index