Recent advances in cellular and molecular biology have substantially increased our understanding of normal and abnormal hypothalamic-pituitary-testicular function. In Male Hypogonadism: Basic, Clinical, and Therapeutic Principles, well-known clinicians and basic scientists comprehensively explain and apply these new insights to the treatment of hypogonadal men. The authors focus on the specific causes of gonadotropin deficiency and testicular failure arising from disorders of the brain and the testis and from gene defects and chronic illness. Additional chapters describe the endocrine mechanism for the decline of testicular function with aging, summarize the data supporting the negative impact of environmental toxins on testicular function, and discuss the testicular consequences of exercise and obesity. Also included is an overview of androgen replacement therapy and a chapter devoted to current approaches to stimulating spermatogenesis in gonadotropin-deficient men.
Comprehensive and highly practical, Male Hypogonadism: Basic, Clinical, and Therapeutic Principles lucidly interprets a large body of scientific information on male reproductive endocrinology to provide a thorough understanding of the pathophysiology, clinical characteristics, and treatments for disorders that adversely affect testicular function.

Klappentext

Recent advances in cellular and molecular biology have markedly increased our understanding of normal and abnormal hypothalamic-pituitary-testicular function. Like other volumes in the Contemporary Endocrinology series, the goal of Male Hy- gonadism: Basic, Clinical, and Therapeutic Principles is to link current knowledge of basic biology to the practice of medicine. The development of new methods for testost- one replacement has substantially increased the number of men who are seeking to determine whether they are hypogonadal, and who are using testosterone replacement therapy, thus mandating a broader understanding of testosterone deficiency. The chapters of this book were contributed by authors from around the world, and from various scientific and clinical disciplines, who have devoted their careers to the study of the physiology and pathophysiology of the male. Thus, this comprehensive and focused volume is intended for a wide audience encompassing both basic scientists and practicing clinicians. Its scope will provide a wealth of information for students and fellows as well.

Inhalt

Neuroendocrine Control of Testicular Function Stephen J. Winters and Alan C. Dalkin Leydig Cell Function in Man Qiang Dong and Matthew P. Hardy Spermatogenesis and Its Regulation in Higher Primates Gary R. Marshall Normal and Delayed Puberty Leo Dunkel Congenital Hypogonadotropic Hypogonadism: Clinical Features and Pathophysiology William F. Crowley and Nelly Pitteloud Male Hypogonadism Resulting From Mutations in the Genes for the Gonadotropin Subunits and Their Receptors Ilpo T. Huhtaniemi Hypogonadism in Males With Congenital Adrenal Hyperplasia Barto J. Otten, Nike M. M. L. Stikkelbroeck, and Ad R. M. M. Hermus Male Hypogonadism Resulting From Disorders of the Pituitary and Suprasellar Region Annamaria Colao, Giovanni Vitale, Michele De Rosa, and Gaetano Lombardi Klinefelter's Syndrome John K. Amory and William J. Bremner Cryptorchidism Peter A. Lee, Barry A. Kogan, and Michael T. Coughlin Hypogonadism in Men With HIV-AIDS Shalender Bhasin Hypogonadism in Men With Chronic Renal Failure Peter Y. Liu and David J. Handelsman Male Hypogonadism Resulting From Cancer and Cancer Treatments Simon J. Howell and Stephen M. Shalet An Ensemble Perspective of Aging-Related Hypoandrogenemia in Men Johannes D. Veldhuis, Ali Iranmanesh, and Daniel Keenan Environmental Causes of Testicular Dysfunction Richard M. Sharpe Exercise and Male Hypogonadism: Testosterone, the Hypothalamic-Pituitary-Testicular Axis, and Physical Exercise Anthony C. Hackney and Jennifer Dobridge Testosterone, SHBG, and the Metabolic Cardiovascular Syndrome Joseph M. Zmuda and Stephen J. Winters Androgen Replacement Therapy in Hypogonadal Men Christina Wang and Ronald S. Swerdloff Stimulation of Spermatogenesis in Hypogonadotropic Men Marion Depenbusch and Eberhard Nieschlag Index