It is now apparent that several fields of investigation are converging upon each other as the goal of finding a practical way to prevent cancer is pursued. The present monograph represents the efforts of an interdisciplinary ESO Task Force that was convened to assess interactions of peptide growth factors and steroid-like molecules in the prevention of cancer. Each of the participants in the Task Force represents a differentscientific discipline, and the monogrph is intended to be a synthesis of their different approaches to the common problem of cancer prevention. It is hoped that the reader will find this monograph to be of use in the evaluation of both preclinical and clinical approaches to the major issues that face us in chemoprevention. It is clear that prevention of cancer is an idea whose time has come, and the problem now is to implement the most effective approaches toward achieving the desired goals.

Inhalt

Concepts of Preneoplasia for the Goal of Cancer Prevention.- Steroids, Retinoids, and their Mode of Action.- Epidermal Growth Factor, Glucocorticoid Hormones and Prolactin Act Sequentially in the Induction of Milk Protein Gene Expression.- Interactions of Retinoids and Transforming Growth Factor-Beta in the Chemoprevention of Cancer.- Growth Regulatory Networks in the Prostate.- Prospects for the Chemoprevention of Breast Cancer.