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Inhalt

Section I: What is a Cell?.- Structure of the Eukaryotic Cell.- Cell and Contractile Protein Evolution.- Discussion.- Section II: Cell Probes.- Immunocytological Methods.- Qualitative and Quantitative Immunoenzymatic Techniques.- Cell Fusion and the Introduction of New Information Into Temperature-Sensitive Mutants of Mammalian Cells.- Various Autoradiographic Methods as a Tool in Cell Growth Studies.- Recent Trends in Electron Microscope Autoradiography.- Growth Parameters in Normal and Tumor Cells: Non-Cycling Cells and Metastatic Variants as Monitored by Flow Cytometry.- Condensed Chromatin: Species-Specificity, Tissue-Specificity and Cell Cycle-Specificity as Monitored by Scanning Cytometry.- Discussion.- Section III: The Cell Cycle.- Growth and Division of Escherichia coli.- Developmental Regulation of Enzyme Synthesis in Saccharomyces cerevisiae.- The Cell Life Cycle and the G1 Period.- The Continuum Model: Application to G1 Arrest and G(0).- Protein and RNA Synthesis.- Cell Cycle Dependence of Erythroid Maturation.- Initiation of DNA Synthesis and Progression through the S Period.- Primary Cilia and Their Role in the Regulation of DNA Replication and Mitosis.- Regulation of Histone Gene Expression During the Cell Cycle and Coupling of Histone Gene Expression With Readout of Other Genetic Sequences.- Chromatin Structure, Histone Modifications and the Cell Cycle.- Histones of Transcriptionally Active and Inactive Chromatin of Mouse Cells.- Minor Components of the Chromatin and Their Role in the Release of Template Restriction.- Higher Order Chromatin Structure, Proteins, c-AMP, Ions Modifications and Cell Cycle Progression: Experimental Results and Polyelectrolyte Theory.- The Organization of Genes in Chromosomes in Some Ciliated Protozoa.- Cell Cycle Phase-specific Changes in Relaxation Times and Water Content in HeLa Cells.- Discussion.- Section IV: Normal Versus Abnormal Cell Growth.- Reverse Transformation of Chinese Hamster Cells by Cyclic AMP and Hormones.- Cell Conformation and Growth Control.- Coupling of Nuclear Morphometry to Cell Geometry. Its Role in the Control of Normal and Abnormal Cell Growth.- Informational Macromolecules in Stationary and Dividing Hepatocytes and Hepatomas.- Cell Growth and Nuclear DNA Increase by Endoreduplication and Differential DNA Replication.- Cell Transformation by RNA Sarcoma Virus.- Molecular Mechanisms of the Control of Cell Growth in Cancer.- Gene Mutation, Quantitative Mutagenesis, and Mutagen Screening in Mammalian Cells: Study with the CHO/HGPRT System.- Round Table Discussion on Mechanisms Controlling Normal Versus Abnormal Cell Growth.- Section V: Cell Kinetics and Clinical Applications.- Clinical Applications of Flow Cytometry.- The Relevance of Cell Kinetics in Determining Drug Activity in vitro.- Cell Kinetics in Clinical Oncology.- Round Table Discussion on "Are Cell Kinetics Useful in Cancer Chemotherapy?".- VI: List of Participants.- VII: Contributor Index.- VIII: Subject Index.