In July 1979, the Faculty of Pharmacy of the University of Bologna received a proposal from Professor Breccia to hold an International Conference on "Nitroimidazoles: Chemistry, Pharmacology and Clinical Application". Because of the great interest in these drugs in various fields, I was very pleased to accept the proposal and to give to the Conference, the sponsorship of the University of Bologna. It was an added pleasure to accept the chairmanship of the meeting, together with Professors Sensi and Adams. At the same time, the Minister of Education approved the proposal also from the Faculty of Pharmacy, to offer an advanced Course on the tOpic: "Radiosensitizers of Hypoxic Cells". This Course was subsequently approved by a special Committee of the NATO Scientific Programme as an Advanced Study Institute. Since the subject matter of both the Conference and the Course are closely inter-related, it was logical to plan the Conference as part of the overall Course. Bringing together specialists from quite different and apparently unrelated fields of research, but all with an interest in the study and application of one single group of drugs, is a novel idea with intriguing possibilities. The volumes of the proceedings include contributions from experts with such diverse interests as synthetic chemistry, mechanism of drug action, parasitology, anaerobic bacteria and protozoa, pharmacology and toxicology, radiation sensitizers for use in radiotherapy and the development of drugs for use in cancer chemotherapy generally.

Inhalt

The Pharmacology and Toxicology of 5-Nitroimidazoles.- Nitroimidazole Chemistry I. Synthetic Methods.- Chemical Properties and Reaction Mechanisms of Nitroimidazoles.- In vivo Testing of Radiosensitizers.- Nitroimidazoles as Hypoxia-Mediated Drugs in Cancer Chemotherapy.- Metronidazole and Misonidazole in Cancer Chemotherapy: Effect of Cell Density on Drug Activity.- Metabolism of Nitroimidazoles.- Mechanism of Cytotoxicity of Nitroimidazoles.- Nitroimidazoles as Antiparasitic Agents.- Resistance to 5-Nitroimidazoles in Pathogenic Microorganisms.- Pharmacokinetics of Nitroimidazoles.- The Clinical Pharmacology of Misonidazole in Radiation Therapy Oncology Group Trials.- Metronidazole and Misonidazole: Absence of Cytogenetic Effects in a Euoxic Bacterial and a Mammalian Cell System in vitro.- Investigations with Nitroimidazoles in Clinical Oncology.- Pharmacokinetic and Therapeutic Studies with Misonidazole and Desmethylmisonidazole in man.- List of Participants.