Tumor Microenvironment

Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis.Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines Part B updates us on what we know about various aspects of the tumor microenvironment, as well as apprises us on future directions in the field. This book is essential reading for advanced cell biology and cancer biology students as well as scientists seeking an update on recent developments and research in the tumor microenvironment.

Provides a comprehensive overview of the state-of-the-art research on the role of chemokines in the tumor microenvironment, including CCL2, CXCL3, CXCL8, CXCL11, CXCL12, CXCL13, CCL24 , CCL25 and CCL27 Discusses the potential of targeting chemokine pathways for the treatment of cancer Describes how chemokines affect cancer immunity and tumorigenesis

Autorentext

Alexander Birbrair received his bachelor's biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette's laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals, including Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

Inhalt

CCL2 in the tumor microenvironment.- CXCL3 signaling in the tumor microenvironment.- CXCL8 Signaling in the Tumor Microenvironment.- CXCL11 signaling in the tumor microenvironment.- CXCL12 signaling in the tumor microenvironment.- CXCL13 signaling in the tumor microenvironment.- CCL24 signaling in the tumor microenvironment.- CCL25 signaling in the tumor microenvironment.- CCL27 signaling in the tumor microenvironment.- Index. <p