Tumor Microenvironment

Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include eosinophils, NK cells, T cells, regulatory T Cells, Langerhans cells, hematopoietic stem cells, Mast cells, B cells and Microglia, and more.

Taken alongside its companion volumes, Tumor Microenvironment: Hematopoietic Cells Part B updates us on what we know about various aspects of the tumor microenvironment as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Provides a comprehensive overview of the state-of-the-art research on the role of hematopoietic components in tumor development and progression Discusses the role of eosinophils, NK cells, ?d T cells, regulatory T Cells, Langerhans cells, Mast cells, B cells and Microglia, and more in the tumor microenvironment Illustrates the functional interaction of hematopoietic stem cells with tumor cells

Autorentext
Alexander Birbrair received his Bachelor's Biomedical degree from Santa Cruz State University in Brazil. He moved to North Carolina, where he finished his PhD in Neuroscience under the mentorship of Osvaldo Delbono. Then, he joined as a posdoc in Stem Cell Biology at Paul Frenette's laboratory at Albert Einstein School of Medicine. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA). He is the Editor-in-Chief of Current Tissue Microenvironment Reports, and associate editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

Inhalt

Eosinophils in the tumor microenvironment.- Dendritic cells in the tumor microenvironment.- Resident memory T cells in the tumor microenvironment.- NK cells in the tumor microenvironment.- T cells in tumor microenvironment.- Regulatory T Cells in the Tumor Microenvironment.- The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem Cells) and Nurture (the Niche).- Langerhans cells in the tumor microenvironment.- Mast cells in the tumor microenvironment.- B cells in the gastrointestinal tumor microenvironment with a focus on pancreatic cancer: opportunities for precision medicine?.- Microglia in the Brain Tumor Microenvironment.- Index.