Transporters in Drug Development

Transporters in Drug Development examines how membrane transporters can be dealt with in academicindustrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters' impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

Answers key questions in drug development Written by leaders in the field Covers both pharmaceutical industry and FDA perspectives

Autorentext

Yuichi Sugiyama had been the Professor, Department of Molecular Pharmacokinetics at the University of Tokyo since 1991, retired from the University of Tokyo, 2012. He is now working as the Head of Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation, Yokohama, Japan. He is a coauthor of more than 580 publications in international journals as well as 270 book chapters and review articles. His research focuses on two areas: 1) Physiologically based pharmacokinetics (In vitro/in vivo extrapolation): 2) Molecular pharmacokinetics of drug transport in liver, kidney, intestine and brain.

His work is internationally recognized by prestigious awards, including AAPS Distinguished Pharmaceutical Scientist Award, 2003, FIP Hoest Madsen Gold Medal in 2009, "Medal with Purple Ribbon" given by Government in 2010 and B.Brodie Award from ASPET in 2012. According to a recent report of ISI Essential Science Indicators, Professor Sugiyama has been ranked as the top (#1) cited scientist in the field of Pharmacology & Toxicology (1997-2007). He served as the chairman of Board of Pharmaceutical Sciences in FIP (2000-2004). He was also the president of both International society for the study of xenobiotics (ISSX) and Japanese Society for Xenobiotic Metabolism and Disposition (JSSX).(2006-2007).

Bente Steffansen is Associate Professor in Transporters in ADME at The Faculty of Health and Medical Sciences, University of Copenhagen. She graduated with MSc (pharm) in 1989 from the Royal Danish School of Pharmacy and obtained her PhD in 1994 under the Danish Research Academy within the field of prodrug design aimed for improved drug delivery. During her PhD she was also a research scientist for 1½ year at the University of Kentucky, USA. She vent to the University of Uppsala in Sweden as visiting scientist in 1996. Shortly hereafter in 1997 she initiated the Molecular Biopharmaceutics research group atthe University of Pharmaceutical Sciences focusing in the beginning on designing prodrugs for the absorptive peptide transporter PEPT1. Her interest for membrane transporters has since then expanded to include many other transporters. Bente has more than 60 research publications, supervised more than 120 Master students for their final research degree and 15 PhD's. In 2010 she edited a book in Molecular Biopharmaceutis, she is a member of the European BioSim network of excellence, and has received several research grants including honorable travel grant. She serves as the Program Director for the Pharmaceutical education at the University of Copenhagen and is a member of the Chemical Committee under the National Pharmacopea Board.

Klappentext

Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver, and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters' impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

Yuichi Sugiyama is head of Sugiyama Laborator at RIKEN Innovation Center, RIKEN Research Cluster for Innovation in Yokohama, Japan, and previously professor in the Department of Molecular Pharmacokinetics at the University of Tokyo from 1991 through to his retirement from the University in 2012. He is coauthor of more than 580 publications in international journals as well as 270 book chapters and review articles. His work is internationally recognized by prestigious awards, including AAPS Distinguished Pharmaceutical Scientist Award (2003), FIP Hoest Madsen Gold Medal (2009), Medal with Purple Ribbon given by the government in 2010, and the B. Brodie Award from ASPET (2012). Professor Sugiyama has been ranked as the top-cited scientist in the field of Pharmacology & Toxicology (19972007). He served as the chairman of the Board of Pharmaceutical Sciences in FIP and was also the president of both theInternational Society for the Study of Xenobiotics (ISSX) and Japanese Society for Xenobiotic Metabolism and Disposition (JSSX).

Bente Steffansen is associate professor in transporters in ADME at the Faculty of Health and Medical Sciences, University of Copenhagen. She graduated with MSc (pharm) in 1989 from the Royal Danish School of Pharmacy and obtained her PhD in 1994 under the Danish Research Academy within the field of prodrug design aimed for improved drug delivery. Dr. Steffansen has published more than 60 research articles, edited a book, and serves as the program director for pharmaceutical education at the University of Copenhagen. She is a member of the Chemical Committee under the National Pharmacopeia Board and a member of the European BioSim network of excellence.

Zusammenfassung

Transporters in Drug Development examines how membrane transporters can be dealt with in academicindustrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters' impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

Inhalt
Membrane Transporters in ADME.- In Vitro Characterization of Transporter Mediated Permeability.- In Vitro Characterization of Interactions with Drug Transporting Proteins.- In Vivo Characterization of Interactions on Transporters.- Application of Targeted Proteomics in ADME for IVIVE.- Prediction of Transporter Mediated Drug-Drug Interaction from In Vitro Data.- Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM).- Analysis of Intestinal Transporters.- Analysis of Hepatic Transport Proteins.- Analysis of Renal Transporters.- The Role of Transporters During Drug Development: Regulatory Science Perspective from the FDA.- Industrial Evaluation of Drug Transporters in ADME.