This volume takes a closer look how the cell organelles Golgi apparatus (also known as the Golgi complex or Golgi body), and centriole are structurally and functionally intertwined.

Initially, it was believed that the role of Golgi complex is limited to the packaging and preparation for secretion of various cellular proteins, while the centriole participates in cell division and cilia formation. However, since their discovery nearly 200 years ago, it became clear that these two organelles are interacting, and that their functions are much more complex and far reaching than previously thought. Recent findings indicate that the GolgiCentriole relationship may be important for directional protein transport, cell polarization and cell cycle progression. Current studies indicate that Golgi and centriole also participate in development and act as cellular and immunological sensors, and that their abnormalities lead to cell and developmental abnormalities, Alzheimer, cancer, variouslipid disorders and neurological and immunological diseases in humans.

This volume combines the latest information on the structure, molecular composition, and roles of Golgi and centriole in various cellular functions and diseases. The better understanding of the Golgicentriole interactions may lead to the development of novel therapies for the treatment of various diseases, including cancer.

First book to address the interactions between the Golgi complex and the centriole Describes the roles of Golgi complex and centriole in cellular functions and diseases Outlines how a better understanding of the Golgicentriole interactions may lead to novel therapies for various diseases

Autorentext

Dr. Malgorzata Kloc completed her PhD in Poland on insect oogenesis, and worked as a tenured Assistant Professor at University of Warsaw. In 1981, she immigrated to Canada and received fellowship from Alberta Heritage Foundation at Calgary University, Alberta, where she studied the heat shock proteins in Xenopus oocytes, and later at Saint Mary's university in Halifax, Nova Scotia, and after that at Dalhousie University in Halifax where she received Terry Fox Foundation fellowship in molecular biology. In 1987, she moved to Houston, USA and worked at MD Anderson Cancer Center on Xenopus germ cell specification and development, and localized mRNA and cytoskeleton. She left MD Anderson in the rank of Associate Professor in 2007 and moved to Houston Methodist Hospital and Research Institute where she currently has a rank of Weill Cornell Professor of cell and molecular biology. At Methodist she studies the role of macrophages, cytoskeleton and RhoA pathway in development of chronic rejection of transplanted organs.

Inhalt
Part I: Golgi and Centriole Structure, Assembly and Regulation.- Chapter 1: The Evolution of Centriole Structure: Heterochrony, Neoteny, and Hypermorphosis.- Chapter 2: The role of protein acetylation in centrosome biology.- Chapter 3: Formins, Golgi and the centriole.- Chapter 4: Role of intracellular transport in the centriole-dependent formation of Golgi ribbon.- Chapter 5: RhoA pathway and actin regulation of the Golgi/centriole complex.- Chapter 6: Multiple roles of Rab GTPases at the Golgi.- Part II: Golgi and Centriole Positioning, Interactions andDynamics.- Chapter 7: Positioning of the Centrosome and Golgi Complex.- Chapter 8: Centriole positioning: not just a little dot in the cell.- Chapter 9: The MTOC/Golgi complex at the T cell immunological synapse.- Chapter 10: Semi-intact cell system for reconstituting and analyzing cellular Golgi dynamics.- Part III: Role of Centriole and Golgi in the Organization of Cell, Embryo and OrganGeometry.- Chapter 11: The centrosome as ageometry organizer.- Chapter 12: Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster.- Chapter 13: Centrosomes in branching morphogenesis.- Chapter 14: MTOC organization and competition during neuron differentiation.- Chapter 15: The Golgi apparatus in polarized neuroepithelial stem cells and their progeny: canonical and non-canonical features.- Chapter 16: Communication of the cell periphery with the Golgi apparatus - a hypothesis.- Part IV: Golgi- and Centriole- related diseases.- Chapter 17: Breaking Bad: Uncoupling of Modularity in Centriole Biogenesis and the Generation of Excess Centrioles in Cancer.- Chapter 18: Centrosome amplification and tumorigenesis cause or effect?.- Chapter 19: Golgi structure and function in health, stress and diseases.- Chapter 20: Selected Golgi-localized proteins and carcinogenesis what do we know?.