Human Neural Stem Cells

Summarizes the most recent advances in human neural stem cells (hNSC) research
Presents hNSC derivation methods
Discusses mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action
Outlines therapeutic potential of human neural stem cells

Summarizes the most recent advances in human neural stem cells (hNSC) research Presents hNSC derivation methods Discusses mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action Outlines therapeutic potential of human neural stem cells

Inhalt
Part 1. Derivation and/or generation of human neural stem cells.- 1. Derivation of neural stem cells from the developing and adult human brain.- 2. Comparison of after-birth and adult somatic tissues in ability to generate human neural stem cells.- 3. Neural stem cells derived from human induced pluripotent stem cells and their use in models of CNS injury.- 4. Generation of human neural stem cells by direct phenotypic conversion.- Part 2. Differentiation and underlying mechanisms.- 5. Epigenetic regulation of human neural stem cell differentiation.- 6. Human iPSC-derived neuronal committed cells reveal common developmental genome deprograming in schizophrenia.- 7. Genome editing in human neural stem and progenitor cells.- 8. Brain Organoids expanding our understanding of human development and disease.- 9. Microenvironmental cues in human neural stem cell fate commitment.- Part 3. Therapeutic potential of human neural stem cells.- 10. Updates on Human Neural Stem Cells: From Generation, Maintenance and Differentiation to Research and Translational Applications.- 11. Human neural stem cells for ischemic stroke treatment.- 12. Modeling pediatric and neuropsychiatric diseases using human iPSC.- 13. Neural stem cell dysfunction in human brain diseases.- 14. Human Fetal Neural Stem Cells for neurodegenerative disease treatment.