This book is a vital resource for understanding apheresis therapy, a crucial intervention in intensive care settings for managing severe medical conditions. Apheresis modalities have significantly influenced medical practices worldwide. This second edition, serves as a compact and practical manual for healthcare professionals, offering critical insights into the application of apheresis in emergency situations.

The chapters cover a wide range of topics, including the basic theory of apheresis, methods for removing pathogenic substances, and various plasma exchange therapies. Expert contributors investigate the selection of blood purification devices, treatment volume determination, and vascular access, while also addressing potential complications such as hypotension, bleeding, and infections. The book also explores the indications and target diseases for apheresis, including autoimmune-related diseases, cardiac conditions, and inflammatory bowel disease.

This indispensable resource is designed for medical students, critical care professionals, and sales representatives involved with apheresis products. It provides a thorough understanding of the latest advancements in apheresis therapy, making it a must-have for anyone in the field. Whether you're a researcher, practitioner, or educator, this book offers valuable knowledge to enhance your expertise in apheresis therapy.

Offers a practical guide for medical professionals and students involved in critical care Explore the essential aspects of apheresis therapy in this book, from basic theory to clinical applications Covers the basic theory of apheresis, treatment methods, complications, indications for various diseases, and more

Autorentext

Dr. Eisei NOIRI

Dr. Eisei Noiri is internationally recognized for his contributions to the field of acute kidney injury and his expertise in acute blood purification therapy and apheresis. From 2005 to 2015, he served as Associate Professor and Head of the Department of Hemodialysis and Apheresis at the University of Tokyo Hospital. During this period, he was actively engaged in clinical practice, research, and education, while also promoting the standardization of therapies to enhance the quality and precision of patient care. Through the National University Liaison Council, these initiatives were disseminated among national university hospitals, contributing to the advancement of high-level clinical practice in Japan.
In the area of apheresis therapyoften performed in critically ill patientsDr. Noiri has advocated for accurate, evidence-based prescriptions, sometimes described as precision apheresis. Such approaches have played an important role in improving patient outcomes. Many of the core techniques of apheresis originated in Japan, and Dr. Noiri has endeavored to present them in a clear and accessible manner for both domestic and international audiences.
The first English edition of this manual was well received in Japan and abroad, including Chinese-speaking regions. The favorable reception of that edition has enabled the publication of this revised second edition. It is the editor's sincere hope that this volume will serve as a useful reference for healthcare teams engaged in apheresis worldwide.

Prof. Kent DOI

Prof. Kent Doi is internationally recognized as a leading authority in acute kidney injury and critical care medicine. Originally trained as a nephrologist and now serving as a critical care physician, he has become one of Japan's most respected key opinion leaders, bridging two disciplines with a rare breadth of expertise.
At the University of Tokyo Hospital, he chairs the Department of Emergency and Critical Care Medicine, where his leadership extends across nephrology, emergency medicine, and disaster medical management. He also serves as President of the Japanese Society for Acute Blood Purification in Critical Care and Vice President of the Japanese Society for Emergency Medicine. In these roles, he plays a pivotal part in shaping the direction of Japan's acute medicine, ensuring that the nation's critical care systemfrom disaster response to pandemic preparednessremains resilient and forward-looking.
Prof. Doi has been at the forefront of integrating big data analytics and artificial intelligence into acute care research, pioneering predictive models that redefine how we anticipate and respond to patient deterioration. His work has helped establish precision medicine approaches in AKI and blood purification, combining advanced science with bedside relevance.
With his broad vision and global standing, Prof. Doi brings both authority and innovation to this revised edition. His editorial guidance has ensured that the book reflects not only Japan's unique leadership in blood purification therapy, but also the evolving international standards of critical care.

Inhalt

Part I Principles and Technologies .-
Chapter 1 Theoretical Background of Apheresis Therapy.-
Chapter 2 Methods to Remove Pathogens.-
Chapter 3 Selection of Plasma Exchange Therapy.-
Chapter 4 Plasma Exchange.-
Chapter 5 Double Filtration Plasmapheresis.-
Chapter 6 Plasma Adsorption.-
Chapter 7 Cryofiltration.-
Chapter 8 Plasma Exchange with Dialysis (PED).-
Chapter 9 Direct Hemoadsorption.-
Chapter 10 Cytapheresis.-
Chapter 11 Cell-Free and Concentrated Ascites Reinfusion Therapy.-
Part II Therapeutic Details .-
Chapter 12 Choice of Apheresis Therapy.-
Chapter 13 Determination of Dosage and Frequency of Therapy.-
Chapter 14 Vascular Access.-
Chapter 15 Anticoagulants.-
Part III Complications .-
Chapter 16 Hypotension.-
Chapter 17 Bleeding Complications and Reduction of Coagulation Factors.-
Chapter 18 Allergies.-
Chapter 19 Electrolyte Disorders.-
Chapter 20 Avoiding Complications During Apheresis.-
Chapter 21 Infections.-
Part IV Autoimmune Disorders .-
Chapter 22 Neurological Diseases.-
Chapter 23 Dermatological Disorders.-
Chapter 24 Kidney Diseases.-
Chapter 25 Malignant Rheumatoid Arthritis and Collagen Diseases.-
Chapter 26 Systemic Lupus Erythematosus.-
Chapter 27 Antiphospholipid Syndrome.-
Chapter 28 ANCA-Associated Vasculitis.-
Chapter 29 Dermatomyositis and Polymyositis.-
Chapter 30 Red Blood Cell Alloimmunization in Pregnancy.-
Chapter 31 Multiple Myeloma.-
Chapter 32 Dilated Cardiomyopathy.-
Part V Pathogens with Large Molecular Weight .-
Chapter 33 Low Density Lipoprotein Apheresis.-
Chapter 34 Endotoxin Absorption Therapy.-
Part VI Diseases Necessary to Supply Coagulation Factors .-
Chapter 35 Liver Disease.-
Chapter 36 Thrombotic Thrombocytopenic Purpura and Thrombotic Microangiopathy.-
Part VII Apheresis in Inflammatory Disorder .-
Chapter 37 Inflammatory Bowel Diseases.-
Part VIII Apheresis in Toxicology .-
Chapter 38 Drug Intoxication.-
Part IX Apheresis in Transplantation .-
Chapter 39 Living Related Kidney Transplantation.-
Chapter 40 Peripheral Blood Stem Cell Transplantation.-
Part X Pediatric Apheresis .-
Chapter 41 Apheresis in Children.