Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes was the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies.Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective field s present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field.New coverage will include signaling pathways for tendon development, molecular mechanisms of tendinopathy, inflammation contribution to healing and pathology of tendons, tendon aging and degeneration, tendon models, and translational studies for tendon regenerative medicine.

Inhalt

Section I Biology and Physiology of Tendons1. Regenerating Tendons: Lessons from Development2. Mechanobiology of Embryonic and Adult Tendons and Tendon Interfaces3. Tendon Physiology and Mechanical Behavior Structure-Function Relationships4. Tendon Resident Cells - Functions and Features5. Molecular and Biological Mechanisms of Tendon Homeostasis and RepairSection II Pathologies and Repair of Tendons6. Tendinopathy Triad - Mechnosenising, ECM, and Inflammation7. Medical Considerations in Tendinopathy8. Etiology, Pathology, and Healing of Tendon Injury and Disease9. Mechanics and Mechanisms of Tendon Disease and Regeneration10. Tendon Aging and Degeneration11. The Veterinarian Perspective: Comparative Anatomy, Animal Models and Bioengineering of TendonsSection III Tendon Tissue Engineering and Regenerative Medicine Approaches12. Cell-Based Approaches for Tendon Regeneration13. Engineering Anisotropic 2D and 3D Structures for Tendon Repair and Regeneration14. Fabrication of Hierarchical and Biomimetic Fibrous Structures to Support the Regeneration of Tendon Tissues15. Multifactorial Tendon Tissue Engineering Strategies16. Tendon Interface Engineering ApproachesSection IV Translating Tendon Regenerative Medicine Strategies17. Transitional Tendinopathy: Are We There Yet?18. Translational Challenges at the Interfaces