Glycobiology of the Immune System and Disease

Autorentext

Dr. Shyamasree Ghosh (MSc, PhD, PGDHE, PGDBI) has worked and published extensively in glycobiology, biology of sialic acids, immunology, stem cells, nanotechnology and computational biology and is currently working as the Scientific Officer, since 2009 in the School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, under Department of Atomic Energy, Govt of India currently located in Jatni, Orissa. ty. She has authored several publications that include books and encyclopedia chapters in reputed journals and books. Research that tries to decode the complexity of life with hopes for a better living forms her research interest.

Klappentext

Glycobiology of the Immune System and Disease explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system. Glycobiology is a rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research. Considering the central role that glycans play in immune interactions, glycoproteins and carbohydrates are becoming the targets of next-generation therapeutics, vaccines and diagnostics. Programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation.

This important reference investigates microbial and mammalian glycans and their protein-binding partners (lectins) and shows the role they play in all innate and adaptive immune responses. With its comprehensive overview of the field, this is an important resource for academicians, graduate and post graduate students as well as professors and faculty in the field of research in glycobiology and immunology.

Inhalt

1. Glycans of the immune system2. C-type lectin in host-pathogen interactions3.Galectins4. Siglecs and the immune system5. CD22 and B cell signalling6. New CD33-related Siglecs in the innate immune System7. Modulation of Immune Tolerance by Siglec-sialic acid interaction8. Siglecs and immune regulation9. Siglecs and the Attenuation of Inflammatory Responses10. The Regulation of the Life Span of Myeloid Cells in the Context of Inflammation by Siglec-8, Siglec-9, and Siglec-F11.Siglecs, Dendritic cells, and T cell activation12. Glycobiology of autoimmunity and chronic inflammation13. Immune response and glycobiology14. Glycobiology of fungus and infection15. Glycobiology of virus and infection16. Glycans as antibody epitopes17. Glycobiology of bacteria and infection18. Glycobiology of tumour and immunity19. Therapeutic strategies based on microorganism and virus protein-glycan interactions