The emerging role of gut microbiota and postbiotics has implications for the management of not only human health and diseases, but also colorectal cancer in particular, as these elements influence colorectal cancer pathogenesis, treatment, and prevention. This book bridges the gap between cutting-edge research and practical clinical applications in the management of colorectal cancer by offering a fresh perspective on potential therapeutic strategies and exploring the significance of microbiota in the oncology landscape. Chapters delve into the specific impacts of postbiotics, linking them to immune response modulation, inflammation reduction, and direct anticancer effects. Chapters also explore current and emerging therapies, including the manipulation of gut microbiota and the use of postbiotics supplements. Clinical trial results, case studies, and expert opinions are interwoven to present a realistic view of the benefits, limitations, and future prospects of these innovative therapeutic strategies.

This book is rounded out with perspectives on future research directions in this area, discussing potential next-generation therapies such as personalized medicine approaches and biotechnological advancements, and further contemplating broader implications of microbiota research on public health strategies. Informative and engaging, this book provides clinicians and researchers alike with a deeper understanding of how postbiotics can be harnessed in colorectal cancer treatment and potentially, the treatment of other cancers influenced by gut health.

Explores the significance of gut microbiota and postbiotics, their impacts on health, and implications for therapies Bridges the gap between cutting-edge research and practical clinical applications in the management of colorectal cancer Clinical trials, case studies, and expert opinions are interwoven to present a realistic view of therapeutic strategies

Autorentext

Dr. Neeraj Mishra is working as Professor and HOI (offg.) in Amity Institute of Pharmacy, Gwalior since July 2019. He has around twenty-one years of teaching and research experience. He worked as brand ambassador of Bentham Science, USA 2018-19. He has guided thirty M Pharm students and guided two Ph.D. students.

He has more than 125 publications of International and National repute in recent concepts of novel drug delivery systems, Oral delivery of Synbiotics, localized drug delivery, targeted and controlled drug delivery of nanocarriers/ microparticles for the treatment of breast, colon cancer, and neurodegenerative disorders. Dr. Mishra more than google scholar 3800 citations with h- index 33 and I index 65 . The total cumulative Impact Factor of his published papers is more than 300 (as per SCOPUS).

He has also written more 15Books and 25 book chapters in Elsevier, Bentham, Springer and Wiley Publication etc. He has also been granted 3 international patents and 2 Indian patents.

Dr. Mishra is recipient of Distinguished Professor Award 2019 from DST-NSTMIS, SPAICS, Indore, and M.P. in September 2019.

Dr. Mishra has received the Distinguished Professor Award '' 2021 from Indian Pharmaceutical Association, MP State Branch, Indore. Dr. Mishra has received Best Academician Award in the Indian Pharmacy Graduate Association, M.P. State International Conference held on 06th May 2023 at DAVV Auditorium, Indore, India.

Dr. Ashish Garg is working as Professor in the Guru Ramdas Khalsa Institute of Science and Technology, Pharmacy, Jabalpur, M.P., since March 2013. He is an author of 50 book chapters and Editor of 8 Books in Elsevier, Wiley, Springer, Bentham, Everest Publication etc., in recent concepts of nanotechnology, novel drug delivery systems, cancer targeting etc. He publisher more than 100 publications of International and National repute in recent concepts of novel drug delivery systems, targeted and controlled drug delivery of nanocarriers/ microparticles for the treatment of lungs, breast, and neurodegenerative disorders. He has also been granted 3 international patents and 10 Indian patents.

Sumel Ashique pursuing from Lovely Professional University, Phagwara, Punjab. He has 4 years of teaching experience & currently working as Assistant Professor at Bengal College of Pharmaceutical Sciences & Research, Durgapur, WB, India. He has achieved 80 publications of International and national accredited reputed journals. He has knowledge in drug delivery, nanotechnology and targeted treatment strategy. He is working as potential reviewer in many well-known publishers (Elsevier, Springer, Taylor and Francis, Dove Press, and Bentham etc.). He has also 5 granted patents from IP and Australia, 20 published book chapters in Bentham, Springer, Elsevier, Bentham and Taylor & Francis. Currently is editing 14 books under CRC Press, Elsevier, Taylor and Francis, Wiley, Nova Science and Springer. He has published 80+ papers including research, reviews, column article, editorial in Scopus, WOS indexed. He is serving as guest editor in JoVE journal (IF 1.2, Scopus & WOS indexed), Current Probiotics (Bentham Science) & Current Indian Science Journal. He is a potential reviewer in Elsevier, springer, Taylor & Francis and Wiley journal for the expertise in the field of targeted drug delivery, nanotechnology, gut-microbiome, postbiotics. Currently he is pursuing his PhD degree from Lovely Professional University, Punjab, India (NAAC A++) in the Pharmaceutical Science department.

Inhalt

Introduction to Gut Microbiota & Postbiotics: Health benefits to human being.- Introduction to Gut Microbiota and its Role in Health and Disease.- Molecular mechanisms of postbiotics in colorectal cancer.- Postbiotics, Metabolic Signalling in colorectal Cancer.- Gut Microbiota and colorectal cancer Pathogenesis.- Gut-microbiota in colorectal Cancer: Fundamentals, analytical techniques and its limitation.- Postbiotics: Bioactive Compounds and Their Effects.- Impact of Diet, Microbiota, and Postbiotics in Colorectal Cancer Management.- The Interplay Between modulation strategies of Gut Microbiota and Colorectal Cancer Development.- The Interplay Between Postbiotics and Colorectal Cancer.- Postbiotics and Colorectal Cancer: Current Research and Clinical Insights.- Gut-Brain Axis and Colorectal cancer: Neuroimmune interactions.- Gut Microbiota, Postbiotics, and Personalized Medicine in CRC.- Therapeutic Strategies of Targeting Gut Microbiota in Colorectal Cancer (CRC) Management.- Integrating Probiotics and Nanotechnology for Enhanced Treatment Efficacy in Colorectal Cancer.- Postbiotics, Gut Microbiota, and Colorectal Cancer: Implications for Immunotherapy.- Microbiota-Targeted Therapies for Colorectal Cancer: Current Challenges and Future Directions.- Diagnostic Approaches for Colorectal Cancer: Gut Microbiota-Based Biomarkers for Colorectal Cancer Detection and Monitoring.- Beyond Treatment: Integrating Gut Microbiota and Postbiotics Survivorship and Long-term Management of Colorectal Cancer.- Future Perspectives: Advancements in postbiotics & Gut Microbiota Research and Potential Therapeutic Breakthroughs.