The leading Textbook on the subject. A completely rewritten and up-to-date fifth edition, based upon the highly respected fourth edition, edited by C. Jacobs, C.M. Kjellstrand, K.M. Koch and J.F. Winchester.

This new edition is truly global in scope and features the contributions of the top experts from around the world.

**The standard reference book for the artificial kidney world.**'** **JAMA** **The aim of the authors - to produce a standard text for nephrologists and those with an interest in today's treatment of renal failure - is fully achieved.'
Urological Research
**`A superb book ... the detail and depth of discussions are unequalled in any current nephrology text.'
Mayo Clinic Proceedings**

Inhalt
Foreword to the fifth edition; B.H. Scribner. Introduction; W.H. Horl, K.M. Koch, R.M. Lindsay, C. Ronco, J.F. Winchester. Contributing authors. Section 1: Pathophysiology of the Uremic Syndrome: Section editor: W. Horl. 1. Molecular basis of uremia; M. Fodinger, G. Sunder-Plassmann. 2. Uraemic toxicity; R. Vanholder, R. de Smet, N. Lameire. 3. The uremic syndrome and pathophysiology of chronic renal failure; W. Horl. 4. Solute transport mechanisms in dialysis; T. Depner. 5. Optimization of high-flux, hollow fiber artificial kidneys; K. Leypoldt, C. Ronco. 6. Peritoneal anatomy and physiology; R.T. Krediet. 7. Biology of hemodialysis; W. Horl. 8. Biology of peritoneal dialysis; N. Topley. Section 2: Technology of Dialysis and Associated Methods: Section Editor: C. Ronco. 9. Vascular access for hemodialysis and its complications; S. Schwabb, B. Canaud. 10. Peritoneal access And its complications; S. Ash. 11. Thrombogenesis and anticoagulation in patients undergoing chronic hemodialysis; J. Bohler. 12. Hemodialysers and related services; N.A. Hoenich, P. Ghezzi, C. Ronco. 13. Membranes for hemodialysis; C. Ronco, P. Ghezzi, S.K. Bowry. 14. Hemodialysis machines and monitors; H.D. Polaschegg, N.W. Levin. 15. Machines for automated peritoneal dialysis; C. Ronco, M. Feriani, R. Dell'Aquila. 16. Machines for continuous renal replacement therapies; C. Ronco , R. Bellomo, A. Brendolan. 17. Water treatment for contemporary hemodialysis; B.J.M. Canaud, N. Levin, Lonnemann. 18. Solutions for peritoneal dialysis; M. Feriani, C. Ronco, G. La Greca. 19. Computerized patient record in dialysis practice; J.A. Lorch, V.E. Pollack. 20. Online monitoring and biofeedback; R.M. Lindsay, D. Schneditz. 21. Hemodialysis fluid composition; F. Locatelli. 22. Adequacy of hemodialysis; R. Suri, P. Blake. 23. Prescription and adequacy of peritoneal dialysis; J. Burkart. 24. Dialysis techniques: 1-Techniques of peritoneal dialysis; R. Gokal. 2-Hemodialysis; F. Locatelli. 3-Continuous renal replacement; C. Ronco, A. Brendolan, R. Bellomo. 4-Daily hemodialysis; U. Buoncristiani. 5-Extracorporeal blood purification; W. Samtleben, M. Lysaght, A. Kaplan. 6-Hemoperfusion; J.F. Winchester. Section 3: Clinical Aspects of Organ Failure in Dialysis Patients: Section editor: J.F. Winchester. 25. Blood pressure control in chronic hemodialysis patients; G. London. 26. Cardiac disease in chronic uremia; P.S. Parfrey. 27. Lipids and atherosclerosis; C. Wanner. 28. Acid-base; M. Feriani, A. Fabris, G. La Greca. 29. Pulmonary aspects of dialysis patients; P.C. D'Haese, M.E. De Broe. 30. Gastrointestinal complications in dialysis patients; J. Gonin, C. Kitiyakara, A. Santos. 31. Neurological and neuromuscular disorders in dialysis patients; A. Davenport. 32. Trace elements in dialysis patients; M.E. De Broe, L.R. Lins, W.A. De Backer. 33. Bleeding