This book describes current methods related to cartilage tissue engineering focusing on the structure and function of native cartilage tissues of hyaline cartilage, fibrocartilage, and elastic cartilage. The book covers topics in modern cartilage tissue engineering including structure-function relationships in native tissue, methods for cartilage tissue engineering and evaluation, animal models. The book concludes with a description of the translational aspects and perspectives.

Provides up-to-date information and methodologies in the field of cartilage tissue engineering Describes the requirements of native cartilages such as in the knee and spine and their implications Offers guidance on the process of bringing a tissue-engineering cartilage product to market

Autorentext

Rachel Nordberg (co-first author) is a research associate at the University of California, Irvine. Her research focus is on the translation of cell therapy products with a particular emphasis on musculoskeletal tissue engineering. She earned her B.S. in Bioengineering from Lehigh University before attending Cornell University for her M.Eng. in Biomedical Engineering. She obtained her Ph.D. in Biomedical Engineering from the University of North Carolina, Chapel Hill and North Carolina State Joint Department of Biomedical Engineering. In 2018, she began her postdoctoral research at the University of California, Irvine where she was awarded a three-year TL-1 NRSA Postdoctoral Fellowship from the UCI Institute of Clinical and Translational Science.

Takumi Takahashi (co-first author) is a postdoctoral fellow at the University of California, Irvine. He earned his B.S. in Bioengineering from the University of California, San Diego and his Ph.D. in Medicine from the Department of Orthopaedic Surgery at Tokai University, Japan. In his postgraduate and postdoctoral work, his research has focused on translating scaffold-less approaches to cartilage tissue engineering for the treatment of musculoskeletal diseases such as osteoarthritis. He has experience in first-in-human clinical studies, conducted for the autologous and allogeneic transplantation of chondrocyte cell-sheets, and in preclinical studies using various small and large animal models.

Jerry Hu is a principal development engineer at the University of California, Irvine. He obtained a PhD in Bioengineering from Rice University and a BSc degree in Chemical Engineering from the University of Texas at Austin. Dr Hu has over 15 years of experience in the study and development of materials, bioreactors, and culture methods for articular cartilage tissue engineering. Jerry has made significant contributions to the research of developing new approaches for cartilage tissue engineering, such as the formation of neotissue without a scaffold, the design and application of mechanical stimulators, and the acquisition of novel autologous cell sources. His direction and collaboration have led to numerous publications, presentations, and other accolades, including the filing of three patents as co-inventor.

Kyriacos A. Athanasiou (corresponding author) has addressed significant societal needs through the development of life-saving technologies. He is a Distinguished Professor at the University of California, Irvine. He is also the holder of the Henry Samueli Chair and the Director of DELTAi (Driving Engineering and Lifescience Translational Advances at Irvine). He has served as a faculty member at the University of Texas, Rice University, and the University of California (first at Davis and now at Irvine). Prof. Athanasiou obtained his PhD in Bioengineering (Mechanical Engineering) from Columbia University in 1989. He has published over 800 peer-reviewed publications, including 400 papers, 370 conference proceedings or abstracts, 20 books, and multiple patents. He has also served as President of the Biomedical Engineering Society, and as the Editor-in-Chief of the Annals of Biomedical Engineering and has received numerous awards. He was elected to the National Academy of Engineering in 2024, the National Academy of Medicine in 2020, and the National Academy of Inventors in 2014.

Inhalt

Chapter 1. An introduction to cartilage.- Chapter 2. Anatomy, structure, and function of select native cartilages.- Chapter 3. Cartilage tissue engineering methods.- Chapter 4. Evaluation assays.- Chapter 5. Animal models.- Chapter 6. Translational considerations.- Chapter 7. Perspectives.