In this book, award-winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. They focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art book provides key insights into cutting edge advances in prostate cancer research, such as laparoscopic radical prostatectomy, and offers a critical evaluation and discussion of opportunities for development of novel therapies for prostate cancer. In addition, it discusses clinical trials that have not been covered or evaluated in any other currently available book. Invaluable to physicians and researchers, Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies provides a comprehensive translational resource as well as an important source of information for prostate cancer patients.

Comprehensive, with up-to-date reviews on all aspects of biology and treatment of prostate cancer Translational resource for clinicians and researchers Discusses recent advances in prostate cancer treatment Provides insight into future, novel treatment strategies

Inhalt
Histopathology and Molecular Biology of Prostate Atrophy.- Epigenetic Gene Silencing in Prostate Cancer.- Inherited Genetic Changes in Prostate Cancer.- Prostate Molecular Oncogenesis.- Somatic Genetic Changes in Prostate Cancer.- Androgen Receptor in Prostate Cancer Progression.- Epigenetic Modification and Acetylation of Androgen Receptor Regulate Prostate Cellular Growth.- Estrogen Receptor ? and ? in the Regulation of Normal and Malignant Prostate Epithelium.- Estrogen Action in Normal Prostate Epithelium and in Prostate Cancer.- Hypoxia-Inducible Factor 1 in the Angiogenesis of Prostate Cancer.- Signal Transduction by the RasMAP Kinase Pathway in Prostate Cancer Progression.- Transcription Factors STAT5 and STAT3.- Role of PI3KAkt and PTEN in the Growth and Progression of Prostate Cancer.- New Perspectives in Prediction of Clinical Outcome of Prostate Cancer.- New Directions in Radiation Therapy of Prostate Cancer.- The Current Knowledge of Hormonal Therapy in the Treatment of Prostate Cancer.- Advances in Surgical Intervention of Prostate Cancer.- Targeted Therapy Trials for Prostate Cancer.- New Perspectives on Chemotherapy in Prostate Cancer.- Concluding Remarks.