This book provides critical insights into and appraisals of recent breakthroughs in type 1 diabetes modulation, with a particular emphasis on the potential impact of current prevention and treatment strategies. It also discusses recent successes and failures in clinical trials. Presenting an comprehensive overview of the disease, it is especially useful for newcomers in the field. It also includes illustrations, which make it easy for the reader to grasp the basic concepts involved. Furthermore, the tables include concise and easy-to-understand information on current clinical trials.

Provides a comprehensive overview for novices in the area of Uses detailed figures to illustrate concepts, making it easy to understand Includes a special section on clinical trials, with an update on the status of research in the area Includes supplementary material: sn.pub/extras

Autorentext

Prachi Singh received her 1st MSc degree in Industrial and Pharmaceutical Sciences from ETH (Zurich) in 2010 and 2nd MSc (research) in Pharmaceutical Science and Technology from National University of Singapore in 2014, working on Dendrimers for drug delivery in type II diabetes. During the period of 2007-2015, she held several positions such as (i) analytical R&D trainee in Novartis AG, Basel, (ii) occupational trainee at the Pharmacy Australian Centre of Excellence, University of Queensland. She is currently a Research Associate at Nanyang Technological University (Singapore) in School of Biological Science. Her research interests focus in Drug delivery and Analytical Biochemistry. Currently she is working on a relatively new potential technology named Weak Affinity Chromatography in fragment-based screening. Ganesh R. Kokil is currently pursuing his PhD degree at the School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Australia, under the supervision of Dr. Harendra S Parekh (medicinal/formulation chemist), Dr. Rakesh N. Veedu (nucleic acid biologist) and Prof. Grant A. Ramm (liver expert). He obtained his pharmacy degree from Shivaji University, India (2004) and Master's in pharmaceutical chemistry from Bharati Vidyapeeth University, India (2007). He is a recipient of the prestigious GATE (Graduate Aptitude Test in Engineering) fellowship for Master's (2005-2007) and University of Queensland International Scholarship for pursuing his PhD studies (2012 to 2015). His areas of research interest include designing, developing, and delivering modified nucleic acid-based therapeutics against type 2 diabetes mellitus with 14 international peer-reviewed publications to his credit. Karnaker R. Tupally is currently pursuing his PhD degree at the School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Australia, under the supervision of Dr. Harendra S Parekh (medicinal/formulation chemist), Dr. Defang Ouyang (formulation/computational chemist). He obtained his pharmacy degree from Kakatiya University, India (2008) and Master's in pharmaceutical analysis & quality assurance from Jawaharlal Nehru technological university, India (2011). He is a recipient of University of Queensland International Scholarship for pursuing his PhD studies (2012 to 2015). Karnaker research involves engineering novel disulfide-contained building blocks for therapeutic applications such as bioreducible peptide dendrimers for gene/drug delivery, design and development of disulfide-bridged therapeutic peptides, molecular dynamic for carrier drug interaction and also exploring other exciting opportunities to use of stable disulfide bridges for labelling biomolecules and drug-conjugates. Aaron Tan is a clinical medical student at University College London (UCL), in the MBBS/PhD clinician-scientist training programme. He obtained both his integrated BSc in Surgical Sciences, and his PhD in Surgery & Bioengineering from UCL. He is also concurrently a visiting scholar at the Biomaterials & Advanced Drug Delivery Laboratory (BioADD) at Stanford University. He has published in excess of 35 peer-reviewed scientific articles and has an h-index of 13. His research interests are in the field of material sciences, bioengineering, and plastic surgery. Prof. Venkatesan has been a Physicist and manager for 17 years with Bell Labs and Bellcore and in the last 17 years has been with the Center for Superconductivity Research at University of Maryland, College Park. He founded the Surface Center at Rutgers University where he was a Professor for about five years (85-90). Most recently he was leading an effort in Oxide Electronics at UMD. Since 2008 he is directing the NanoCore Research Center at the National University of Singapore. He pioneered the Pulsed Laser deposition process and was the first to elucidate the intricacies of the process to make this a reproducibl

Inhalt

Introduction to Diabetes and Type 1 Diabetes.- Triggers Causing Type 1 Diabetes.- Predictors and Pathogenesis of Type 1 Diabetes.- Type 1 Diabetes: Past Present and Future Therapies.