Phosphodiesterases as Drug Targets

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Along with its coverage of fresh and emerging ideas in this key field, the book examines all the major concepts related to the design and use of PDE inhibitors.

provides a summary of the major concepts related to the design and use of PDE inhibitors describes exciting ideas and developments that are currently emerging in this dynamic and important field written by leading authorities in the field Includes supplementary material: sn.pub/extras

Inhalt
Phosphodiesterase inhibitors: History of pharmacology; PDE inhibitors: factors that influence potency, selectivity and action; A fission yeast-based platform for phosphodiesterase inhibitor high throughput screening and analyses of phosphodiesterase activity; The pharmacokinetics of PDE inhibitors and the impact of this on their efficacy and the therapeutic window; Structural insight into the substrate specificity of phosphodiesterases; The GAF-tandem domain of phosphodiesterase 5 as a potential drug target; Small molecule allosteric modulators of phosphodiesterase 4; PDE 2 holoenzyme-insights about full length PDE and mechanism of activation by cGMP binding; Harnessing the clinical efficacy of phosphodiesterase 4 inhibitors in inflammatory lung diseases with dual-selective phosphodiesterase inhibitors and novel combination therapies; PDE inhibitors in the treatment of inflammatory diseases; Cyclic nucleotides and phosphodiesterases in monocyte differentiation; PDEs as targets for modulating T cell responses; Role of PDEs in adult-onset pulmonary arterial hypertension; Phosphodiesterases: emerging therapeutic targets for neonatal pulmonary hypertension; Phosphodiesterase inhibition in heart failure Evaluation of the Therapeutic Utility of Phosphodiesterase 5A Inhibition in the mdx Mouse Model of Duchenne Muscular Dystrophy; PDEs as targets for intermittent claudication; Treatment of erectile dysfunction and lower urinary tract symptoms by phosphodiesterase inhibitors; Regulation of endothelial barrier function by cyclic nucleotides: the role of phosphodiesterases; Potential use of PDE inhibitors in treatment of depression and improvement of cognition; PDEs as targets for the treatment of basal ganglia disorders Therapeutic potential of PDE inhibitors in parasitic diseases