The oral cavity is a complex environment from an immunological perspective. Chronic exposure of the oral cavity to a plethora of microorganisms and antigens highlights the importance of the role of mucosal and systemic immune system protection against these microbes and particles.

Nevertheless, dysregulation of the host-immune interaction may be the main cause of some chronic oral conditions, such as periodontal diseases. The clinical relevance of the association between oral pathological conditions and the occurrence of systemic diseases has increased clinicians' interest in understanding the underlying pathophysiologic mechanisms of this clinical relationship. On the other hand, oral manifestations are one of the primary signs of Primary and Secondary Immunodeficiency Diseases, Immune Dysregulations, and Autoimmunity in some cases; this can be an effective diagnostic approach that should not be overlooked.

In this book, the mechanism of oral tolerance and probable causes of its imbalance will be addressed. As the assessment of interrelationship between immunity and oral cavity is still understudied from numerous aspects, this book aims to conduct a comprehensive evaluation of how oral diseases may be the leading cause for the development of different systemic conditions. It also explores the clinicopathological roles of the immunological factors in oral pathological conditions such as oral malignancies, chronic diseases, and other oral lesions. In addition to mucosal immunology of the oral cavity, the future perspectives of oral mucosal immunotherapy are among the emerging issues of the past decade that will be discussed comprehensively in this book.

Explore how oral immunity shapes systemic health, from diabetes to neurodegeneration Uncover the role of oral microbes in inflammation, immunity, and chronic disease links Bridge oral and systemic health with cutting-edge insights on immune-microbiome crosstalk

Autorentext

Professor Nima Rezaei gained his medical degree (MD) from Tehran University of Medical Sciences and subsequently obtained an MSc in Molecular and Genetic Medicine and a PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Pediatric Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Professor Rezaei is now the Full Professor of Immunology and Vice Dean of Research and Technologies, School of Medicine, Tehran University of Medical Sciences, and the co-founder and Head of the Research Center for Immunodeficiencies. He is also the Founder of the Universal Scientific Education and Research Network (USERN). Prof. Rezaei supervised more than two hundred research projects and designed and participated in several international collaborative projects. Prof. Rezaei is the editor, editorial assistant, or editorial board member of more than fifty international journals. He edited more than one hundred international books, presented more than a thousand lectures in congresses/meetings, and published more than 1,500 scientific papers in the international journals.

Dr. Heliya Ziaei earned her Doctor of Dental Surgery (DDS) from Tehran University of Medical Sciences in 2020 and is currently completing her PhD in Craniofacial Molecular Biology at the Herman Ostrow School of Dentistry, University of Southern California. She has contributed to several interdisciplinary research projects in the areas of oral biology, craniofacial developmental science, and regenerative medicine. Dr. Ziaei served as Executive Director and Deputy of International Affairs at the Universal Scientific Education and Research Network (USERN). She has co-authored several peer-reviewed scientific articles and book chapters and has presented more than twenty lectures at academic conferences and meetings.

Inhalt

Part I. Introduction to Oral Immunity and Host-Microbe Interactions .- Chapter 1. Introduction on Oral Immunity.- Chapter 2. Oral Innate Immunity and the Role of Oral Epithelial Cells.- Chapter 3. Examining Oral Microbial Communities at the Gingival Interface during Health and Inflammatory Diseases.- Chapter 4. The Role of Short-Chain Fatty Acids Produced by Oral Bacteria in Modulating Oral Immunity.- Part II. Oral-Systemic Health Connections .- Chapter 5. Periodontitis and Systemic Health: An Interconnected Relationship.- Chapter 6. Oral Microbiome, Oral Hyperpermeability, and Periodontitis in Metabolic Syndrome.- Chapter 7. Diabesity and Oral Immunity: Exploring the Interconnection.- Chapter 8. Endodontic Inflammatory Disease: Systemic Consequences.- Chapter 9. Periodontal Disease and Osteoporosis: A Bidirectional Relationship.- Chapter 10. Immunological Diagnosis and Treatments of Periodontitis in Patients with Type 2 Diabetes Mellitus.- Chapter 11. Impact of Maternal Immune Response on Oral Health and Pregnancy Outcomes.- Chapter 12. Salivary Immune and Endocrine Biomarkers in Skin and Mucocutaneous Diseases.- Chapter 13. Impact of Oral Immunity on Neuroinflammation and Neurodegenerative Diseases.- Chapter 14. Oral Manifestations of Autoimmune Diseases.- Chapter 15. Recent Insights on Dental Caries Microbiota in Pediatric Patients with Inborn Errors of Immunity.- Part III. Immunopathology of Oral Diseases and Cancer .- **** Chapter 16. Inflammasomes in Oral Pathologies: From Periodontal Disease to Oral Cancer.- Chapter 17. The Role of Proinflammatory Biomarkers in Oral Cancer Pathophysiology.- Chapter 18. Characterizing the Head and Neck Cancer Microenvironment: Implications for Immunotherapy and Prognosis.- Chapter 19. In Silico Analysis of Squamous Cell Carcinoma.- Chapter 20. Infectious/inflammatory oral diseases and medication-related osteonecrosis of the jaw (MRONJ).- Chapter 21. Inflammatory Mediators in Peri-implantitis: From Pathophysiology to Therapeutic Targets.- Chapter 22. Titanium Dental Implant Corrosion in Peri-Implantitis and Implant Failure.- Chapter 23. Innate Immunity Gene Variants Affect Periodontitis Susceptibility.- Part IV. Bone Metabolism, Orthodontics, and Immunological Interactions .- Chapter 24. Oral and Craniofacial Development and Immunology.- Chapter 25. Immune Involvement in the Development and Maintenance of Oral and Craniofacial Bones.- Chapter 26. Crosstalk Between Hematopoietic and Mesenchymal Cells in Bone and Tooth Immune Response.- Chapter 27. The Interplay of Immune Response and Dental Enamel Formation in Health and Sickness.- Chapter 28. Immune Responses in Orthodontic Treatment.- Chapter 29. Evaluating the Impact of Clear Dental Aligners on Dental and Periodontal Conditions, Oral Microbial Patterns, and the Immune System.- Part V. Therapeutic Strategies and Future Directions in Oral Immunology .- Chapter 30. Immunomodulation Strategies in Oral Diseases: From Microbiome Manipulation to Pro-Resolution Therapies.- Chapter 31. Modulating the Allergen-Specific Immune Response to Achieve Remission of Food Allergy Through Oral Immunotherapy.- Chapter 32. Functions of Macrophages in Periodontal Disease Progression and Gingival Tissue Homeostasis.- Chapter 33. Immune and Stem Cell Interactions in Periodontal Disease: The Regulatory Role of Toll-Like Receptor 3.- Chapter 34. Immunomodulatory Effects of Medicinal Plants.- Chapter 35. Immunomodulation Strategies to Enhance Oral Bone Regeneration.- Chapter 36. Salivary Proteome Role in Infection and Immunity.- Chapter 37. Dental Pulp-Derived Stem Cells in Mitigating Inflammatory Arthritis and Their Mechanisms in Conjunction with Oral Diseases.- Chapter 38. Innovative Biomarkers for Oral Immunity: Advancements and Clinical Applications.