Since its first discovery in the early 90's, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.

Written by experts of the field, NF-kB/Rel Transcription Factor Family covers topics from structural basis and molecular mechanism of NF-kB signal transduction, transcriptional regulation, and target gene expression to the roles of NF-kB in biological and pathological processes. Includes supplementary material: sn.pub/extras

Klappentext

Since its first discovery in the early 90 s, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.

Inhalt
Structural Analysis of NF-?B and I?B Proteins.- NF-?B Signal Transduction by IKK Complexes.- Receptors and Adaptors for NF-?B Signaling.- Cellular Dynamics of NF-?B Associated Proteins.- NF-?B in Lymphopoiesis.- NF-?B and Immune Cell Effector Functions.- Roles of NF-?B in Autoimmunity.- The Central Role of NF-?B in the Regulation of Immunity to Infection.- Molecular Basis of Oncogenesis by NF-?B.- NF-?B in Human Cancers.- NF-?B in Neurons.- Inhibitors of NF-?B Activity.