Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

Offers cutting-edge information on the development of antibody drug conjugates and recombinant immunotoxins Explores related basic biological and chemical technologies and promotes new developments toward clinical applications Primarily aimed at postgraduate students, researchers and clinicians

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Chemical Assembly of Antibody-Drug Conjugates.- Pre-clinical evaluation of ADCs delivering highly potent pyrrolobenzodiazepine (PBD) dimers.- Stable and homogeneous drug conjugation by sequential bis-alkylation at disulfide bonds using bis-sulfone reagents.- Calicheamicin antibody-drug conjugates for liquid- and solid tumor indications.- Enzyme-based strategies to generate site-specifically conjugated Antibody Drug Conjugates.- Substance P Saporin for the Treatment of Intractable Pain.- Recombinant immunotoxins for Chronic Inflammatory Disease.- BL22: A milestone in targeting CD22.