New Generation Vaccines

It is widely accepted that vaccination still renains the best answer to ITDst infectious diseases. Recently, vaccine developnent has been greatly facilitated by advances in ITDlecular and cell biology which have laid the foundations of a new generation of vaccines. '!hese are exemplified by submit vaccines produced through gene cloning and synthetic peptides mimicking snall regions of proteins on the outer coat of viruses and capable of eliciting virus neutralizing antibodies. However, submit and peptide vaccines are only weakly or non-inmmogenic in the absence of immunological adjuvants. The latter are a diverse array of agents that augment specific cell-mediated immune responses to the antigens and the formation of protective antibodies. '!his book contains the proceedings of the 3rd NATO Advanced Studies Institute (ASI) "New-Generation vaccines: '!he Role of Basic Irrmmology" held at Cape Sounion Beach, Greece, during 24 June-5 July, 1992. It deals with recent developnents in the understanding of inmmity at the ITDlecular and cellular levels and the application of such knowledge in the search for novel inmmological adjuvants and the fonnulation of new-generation vaccines for experimental and clinical use. We express our appreciation to Professor K. Dalsgaard and H. Snippe for their cooperation in planning the ASI and to Mrs. Concha Perring for her excellent production of the manu scripts. '!he ASI was held tmder the sponsorship of NATO Scientific Affairs Division and generously co-sponsored by SrnithKline Beecham Pharmaceuticals (Fhiladelp,. ia). Financial assistance was also provided by Pasteur Merieux (Marcy L'Etoile), British Biotechnology Ltd.

Klappentext

Proceedings of a NATO ASI held at Cape Sounion Beach, Greece, June 24-July 5, 1992.

Zusammenfassung
Proceedings of a NATO ASI held at Cape Sounion Beach, Greece, June 24-July 5, 1992.

Inhalt
Dendritic Cells: Nature's Adjuvants.- The Multiple Accessory Cell Concept: Its Relevance to the Development of Adjuvants and Vaccines.- Synthetic Peptides and the Role of T-Helper Cell Determinants.- Carriers for Peptides: Theories and Technology.- Co-entrapment of T-Cell and B-Cell Peptides in Liposomes Overcomes Genetic Restriction in Mice and Induces Immunological Memory.- Preparation and Characterization of Stable Liposomal Hepatitis B Vaccine.- Initiation of Immune Response with ISCOM.- Nanoparticles as Potent Adjuvants for Vaccines.- Optimization of Carriers and Adjuvants: A Model Study Using Semliki Forest Virus Infection of Mice.- Immunotargeting as an Adjuvant-Independent Subunit Vaccine Design Option.- BCG Vaccine: The Next Generation of Targeted Drug Delivery Systems.- Significance of Virulence Factors and Immuno-Evasion for the Design of Gene-Deleted Herpesvirus Marker Vaccines.- Eradication of Sylvatic Rabies Using a Live Recombinant Vaccinia-Rabies Vaccine.- Vaccination of Wildlife: The Role of Recombinant Poxvirus Vaccines.- Recombinant Protein Antigens with Built-in Adjuvanticity.- Vaccination against Malaria; the Anti-Disease Concept.- Progress in the Development of Epstein-Barr Virus Vaccines.- Requirements for Induction of Semliki Forest Virus Neutralizing Antibodies by a Non-Internal Image Monoclonal Antibody.- Polysaccharide Vaccines.- Liposomal Delivery of Cytokines: A Means to Improve their Therapeutic Performance.- Participants Photograph.- Contributors.