A distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age. Topics range from the cellular and molecular changes that occur with aging-especially aging-associated activation of astrocytes and microglia and its relation to neuronal injury and repair-to neuron-glia intercommunication. The contributors show how glial signals may be modulated by hormones, growth factors, neurotransmitters, intracellular metabolism, and intercellular exchanges, as well as by aging of the blood-brain barrier.

Includes supplementary material: sn.pub/extras

Klappentext
With the proportion of the aged in the population rapidly increasing, especially those 80 and beyond, it has become imperative to understand not only how to prevent and treat the disabilities and diseases of old age, and to prolong and improve functional ability. The biology of neuroglia has thus emerged as one of the most exciting research areas in the neurosciences. In Neuroglia in the Aging Brain, Jean de Vellis and a distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age. Topics range from the cellular and molecular changes that occur with aging-especially aging-associated gliosis in astrocytes and its relation to neuronal injury and repair-to neuron-glia intercommunication. The contributors show how glial signals may be modulated by hormones, growth factors, neurotransmitters, intracellular metabolism, and intercellular exchanges, as well as by aging of the blood-brain barrier. Also discussed is the role of the neuroglia, especially of the astrocytes and microglia, in the etiology of several neurodegenerative diseases, as well as the possibilities for therapeutic interventions in glial responses, and indirectly on neurons.
Illuminating and multidisciplinary, Neuroglia in the Aging Brain provides today's neuroscientists and neuropathologists with powerful new insights into how glial cells are involved in the pathogenesis of major aging disorders and how they may be used therapeutically to encourage neuronal self-renewal.

Inhalt
1 • Neuromorphological Changes in Neuronal and Neuroglial Populations of the Cerebral Cortex in the Aging Rat: Neurochemical Correlations.- 2 • Diversity in Reactive Astrocytes.- 3 • Astrocytic Reaction After Traumatic Brain Injury.- 4 • Astrocytes In Situ Exhibit Functional Neurotransmitter Receptors.- 5 • Glia and Extracellular Space Diffusion Parameters in the Injured and Aging Brain.- 6 • Intercellular Diffusional Coupling between Glial Cells in Slices from the Striatum.- 7 • Glial Cell Involvement in Brain Repair and the Effects of Aging.- 8 • ATP Signaling in Schwann Cells.- 9 • Gliosis Growth Factors in the Adult and Aging Rat Brain.- 10 • Role of Fibroblast Growth Factor-2 in Astrogliosis.- 11 • Trophins as Mediators of Astrocyte Effects in the Aging and Regenerating Brain.- 12 • Responses in the Basal Forebrain Cholinergic System to Aging.- 13 • Effects of Estrogens and Thyroid Hormone on Development and Aging of Astrocytes and Oligodendrocytes.- 14 • Neurotoxic Injury and Astrocytes.- 15 • Ammonium Ion Transport in Astrocytes: Functional Implications.- 16 • Molecular Anatomy of the Blood-Brain Barrier in Development and Aging.- 17 • The Blood-Brain Barrier in the Aging Brain.- 18 • Astrocytes and Barrier-provided Microvasculature in the Developing Brain.- 19 • Microglial and Astrocytic Reactions in Alzheimer's Disease.- 20 • Activated Neuroglia in Alzheimer's Disease.- 21 • Reactive Astroglia in the Ataxic Form of Creutzfeldt-Jakob Disease: Cytology and Organization in the Cerebellar Cortex.- 22 • Ischemic Injury, Astrocytes, and the Aging Brain.- 23 • Glial-Neuronal Interactions during Oxidative Stress: Implications for Parkinson's Disease.- 24 • Astrocytic Changes Associated with Epileptic Seizures.- 25• Synaptic and Neuroglial Pathobiology in Acute and Chronic Neurological Disorders.- 26 • Astrocytes and Ammonia in Hepatic Encephalopathy.